Sig Radiation induced Allele Detail MGI Mouse (MGI:1861182)

Sig
Radiation induced Allele Detail

Nomenclature

Symbol:	Sig
Name:	sightless
MGI ID:	MGI:1861182
Gene:	Sig Location: unknown Genetic Position: Chr6, 1.0 cM

Mutation
origin

Strain of Origin:

(C3H/HeH x 101/H)F1

Mutation
description

Allele Type:	Radiation induced
Inheritance:	Semidominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sig Mutation:	1 strain or line available

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found

Affected Systems	Genotypes:	hm1	hm2	ht3
hearing/vestibular/ear			√
abnormal ear morphology			√
abnormal cochlea morphology			√
absent endolymphatic duct			√
absent endolymphatic sac			√
abnormal crista ampullaris morphology			√
abnormal membranous labyrinth			√
abnormal cochlear labyrinth			√
abnormal saccule morphology			√
abnormal utricle morphology			√
abnormal utricular macula morphology			√
		hm1	hm2	ht3
lethality/prenatal-perinatal		√
perinatal lethality		√
		hm1	hm2	ht3
limbs/digits/tail		√
abnormal paw/hand/foot morphology		√
syndactyly		√
		hm1	hm2	ht3
nervous system		√		√
hydroencephaly		√		√
		hm1	hm2	ht3
vision/eye				√
eyelids open at birth				√
binocular blindness				√

Phenotypic
data by
genotype

Phenotypic Data by Genotype

(show or hide all phenotypic details)

Genotype	Allelic Composition	Genetic Background
hm1	Sig/Sig	involves: 101/H * C3H/HeH * T Stock
lethality/prenatal-perinatal perinatal lethality (J:13435) all homozygotes die sometime around birth limbs/digits/tail abnormal paw/hand/foot morphology (J:13435) some have hindfoot anomalies, notably syndactyly syndactyly (J:13435) nervous system hydroencephaly (J:13435) in all homozygotes, more pronounced in the homozygote than the heterozygote
Genotype	Allelic Composition	Genetic Background
hm2	Sig/Sig	involves: 101/H * C3H/HeH
hearing/vestibular/ear abnormal ear morphology (J:136112) abnormal cochlea morphology (J:136112) absent endolymphatic duct (J:136112) absent endolymphatic sac (J:136112) abnormal crista ampullaris morphology (J:136112) abnormal membranous labyrinth (J:136112) only one anomalous semi-circular duct is present abnormal cochlear labyrinth (J:136112) poorly coiled abnormal saccule morphology (J:136112) abnormal utricle morphology (J:136112) abnormal utricular macula morphology (J:136112) macula is missing
Genotype	Allelic Composition	Genetic Background
ht3	Sig/Sig⁺	involves: 101/H * C3H/HeH * T Stock
vision/eye eyelids open at birth (J:5021, J:13435) both eyes are open at birth, leading to blindness (J:5021) fully penetrant dominant mutation (J:13435) binocular blindness (J:13435) nervous system hydroencephaly (J:13435) slight in the heterozygote

Notes

Found in a low-intensity neutron irradiation experiment.

References

Original:	J:5021 Batchelor AL et al., "A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia." Mutat Res 1966 Jun;3(3):218-29
All:	3 reference(s)

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