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Gbx2 Gene Detail
 Symbol
Name
ID
Gbx2
gastrulation brain homeobox 2
MGI:95668


Nomenclature History
Synonyms Gbx-2, MMoxA, Stra7
Genetic Map
Chromosome 1
65.0 cM, cytoband C5-E1
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr1:91824559-91827751 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gbx2 ± 2 cM)
TreeFam: TF351530
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000034486 Ensembl Gene Model | MGI Sequence Detail 3193 C57BL/6J ± Kb
transcript NM_010262 RefSeq | MGI Sequence Detail 2126 C57BL/6
polypeptide P48031 UniProt | EBI | MGI Sequence Detail 348 Not Applicable
For the selected sequences
All sequences(18)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(1) Targeted, other(4)
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.
Polymorphisms RFLP(1) SNPs within 2kb(2 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(25)
Process autonomic nervous system development, axon guidance...
Component nucleus
Function DNA binding, sequence-specific DNA binding...
External Resources: MouseFunc
Expression Literature Summary: (120 records)
Data Summary: Assays (22)    Results (311)    Tissues (197)    Images (89)
Theiler Stages: 2,3,4,5,11,12,13,14,15,17,19,20,21,22,24,28
  Assay Type Assays   Results
      RT-PCR 1   15
      RNA in situ 21   296
cDNA source data(12)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(13) Primer pair(2) Other(8)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000034486
UniGene 204730
DFCI TC1589068
Entrez Gene 14472
International Mouse Knockout Project Status Gbx2
Protein
domains
InterPro ID Description
IPR001356 Homeobox
IPR009057 Homeodomain-like
IPR012287 Homeodomain-related
IPR017970 Homeobox, conserved site
IPR020479 Homeobox, region
Graphical View of Protein Domain Structure
References
(Earliest) J:2276 Murtha MT et al., "Detection of homeobox genes in development and evolution." Proc Natl Acad Sci U S A 1991 Dec 1;88(23):10711-5
(Latest) J:152319 Calmont A et al., "Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm." Development 2009 Sep;136(18):3173-83
All references(135)
Other
accession IDs
MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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