Symbol
Name
ID
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Synonyms
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Cavbeta2, Cchb2
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(37)
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Alleles
and
phenotypes
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All alleles(3) :
Targeted, knock-out(2)
Targeted, other(1)
| Mice homozygous for a null allele exhibit lethality at E10.5 with growth retardation, abnormal yolk vasculature and abnormal cardiac development and function. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(1127 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (4 records)
Data Summary:
Assays (5)
Results (45)
Tissues (25)
Images (9)
Theiler Stages: 15,17,20,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
2 |
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6 |
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RNA in situ |
2 |
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22 |
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Immunohistochemistry |
1 |
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17 |
cDNA source data(9)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(19)
Genomic(2)
cDNA(15)
Primer pair(1)
Other(1)
Antibodies(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000584 |
Voltage-dependent calcium channel, L-type, beta subunit |
| IPR001452 |
Src homology-3 domain |
| IPR005444 |
Voltage-dependent calcium channel, L-type, beta-2 subunit |
| IPR008145 |
Guanylate kinase/L-type calcium channel |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:25718
Massa E et al.,
"Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms."
Mol Pharmacol 1995 Apr;47(4):707-16
(Latest)
J:152311
Neef J et al.,
"The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing."
J Neurosci 2009 Aug 26;29(34):10730-40
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All references(23)
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Other
accession IDs
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MGD-MRK-24068, MGI:103200, MGI:2139283, MGI:3583767
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