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Duox2 Gene Detail
 Symbol
Name
ID
Duox2
dual oxidase 2
MGI:3036280


Nomenclature History
Synonyms A430065P05Rik, LNOX2, NOXEF2, P138-TOX, THOX2
Genetic Map
Chromosome 2
Syntenic
 
Mapping data( 1)
Sequence Map
Chr2:122104983-122123901 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; pig, domestic; rat    (Mammalian Orthology)
TreeFam: TF105424
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000015565 VEGA Gene Model | MGI Sequence Detail 18919 C57BL/6J ± Kb
transcript NM_177610 RefSeq | MGI Sequence Detail 4554 -
polypeptide NP_808278 RefSeq | MGI Sequence Detail 1517 -
For the selected sequences
All sequences(14)
Alleles
and
phenotypes
All alleles(3) : Targeted, other(2) Spontaneous(1)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(130 from dbSNP Build 128)   SNPs within 2kb including multiple locations(144)
Gene Ontology
(GO)
classifications
All GO classifications(13)
Process adenohypophysis morphogenesis, bone mineralization...
Component integral to membrane, membrane...
Function calcium ion binding, oxidoreductase activity...
External Resources: MouseFunc
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (7)    Tissues (2)    Images (1)
Theiler Stages: 28
  Assay Type Assays   Results
      RT-PCR 2   7
cDNA source data(5)
External Resources: GEO 
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000068452
DoTS DT.91582293
UniGene 358846
DFCI TC1594427
NIA Mouse Gene Index U023274
Entrez Gene 214593
VEGA Gene Model OTTMUSG00000015565
International Mouse Knockout Project Status Duox2
Protein
domains
InterPro ID Description
IPR002007 Haem peroxidase, animal
IPR002048 Calcium-binding EF-hand
IPR010255 Haem peroxidase
IPR011992 EF-hand-like domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase-like transmembrane component, N-terminal
IPR017927 Ferredoxin reductase-type FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel
IPR018247 EF-Hand 1, calcium-binding site
IPR018248 EF-Hand domain
IPR018249 EF-HAND 2
IPR019791 Haem peroxidase, animal, subgroup
References
(Earliest) J:83395 Sandell LL et al., "Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta." Proc Natl Acad Sci U S A 2003 Apr 15;100(8):4622-7
(Latest) J:142401 Cheret C et al., "Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase." J Neurosci 2008 Nov 12;28(46):12039-51
All references(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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