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Otos Gene Detail
 Symbol
Name
ID
Otos
otospiralin
MGI:2672814

Nomenclature History
Genetic Map
Chromosome 1
Syntenic
 
Mapping data( 1)
Sequence Map
Chr1:94540796-94545418 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF336889
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000044055 Ensembl Gene Model | MGI Sequence Detail 4623 C57BL/6J ± Kb
transcript NM_153114 RefSeq | MGI Sequence Detail 814 -
polypeptide Q8R448 UniProt | EBI | MGI Sequence Detail 89 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes 		All alleles(1) : Targeted, knock-out(1)
Homozygous null mice display decreased endocochlear potentials and shrunken type II and IV cochlear fibrocytes.
Polymorphisms SNPs within 2kb(54 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(2)
Process sensory perception of sound
Component extracellular region
External Resources: MouseFunc
Expression Literature Summary: (1 records)
cDNA source data(10)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(10) cDNA(10)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000044055
DoTS DT.101714117, DT.91573154
UniGene 219545
DFCI TC1587653, TC1684522
NIA Mouse Gene Index U021603
Entrez Gene 260301
International Mouse Knockout Project Status Otos
References
(Earliest) J:85737 Delprat B et al., "Downregulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafness." J Neurosci 2002 Mar 1;22(5):1718-25
(Latest) J:134489 Trowe MO et al., "Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes." Development 2008 May;135(9):1725-34
All references(4)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory