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Esrrb Gene Detail
 Symbol
Name
ID
Esrrb
estrogen related receptor, beta
MGI:1346832


Nomenclature History
Synonyms ERR2, Err2, ERRb, Estrrb
Genetic Map
Chromosome 12
41.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr12:87702067-87862575 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Esrrb ± 2 cM)
Protein SuperFamily: estrogen receptor-like nuclear receptor
TreeFam: TF323751
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023036 VEGA Gene Model | MGI Sequence Detail 160509 C57BL/6J ± Kb
transcript NM_001159500 RefSeq | MGI Sequence Detail 4309 C57BL/6
polypeptide Q61539 UniProt | EBI | MGI Sequence Detail 433 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes
All alleles(212) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(208)
Mice homozygous for disruptions in this gene die as embryos around E9.5 or E10.5 as a result of failure of the chorion to develop and subsequent placental defects.
Polymorphisms RFLP(1) SNPs within 2kb(625 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(21)
Process embryonic placenta development, in utero embryonic development...
Component nucleus
Function DNA binding, ligand-dependent nuclear receptor activity...
External Resources: MouseFunc
Expression Literature Summary: (16 records)
Data Summary: Assays (16)    Results (165)    Tissues (110)    Images (79)
Theiler Stages: 2,3,4,5,7,8,9,10,11,13,15,17,18,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 4   39
      RNA in situ 8   104
      Immunohistochemistry 2   16
      Northern blot 2   6
cDNA source data(26)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(34) Genomic(2) cDNA(27) Primer pair(3) Other(2) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021255
DoTS DT.101384607, DT.40181227, DT.97378576
UniGene 235550
DFCI TC1598975, TC1629454
NIA Mouse Gene Index U014218
Entrez Gene 26380
VEGA Gene Model OTTMUSG00000023036
International Mouse Knockout Project Status Esrrb
Protein
domains
InterPro ID Description
IPR000003 Retinoid X receptor
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR013088 Zinc finger, NHR/GATA-type
Graphical View of Protein Domain Structure
References
(Earliest) J:31609 Pettersson K et al., "Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis." Mech Dev 1996 Feb;54(2):211-23
(Latest) J:140350 van den Berg DL et al., "Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression." Mol Cell Biol 2008 Oct;28(19):5986-95
All references(26)
Other
accession IDs
MGD-MRK-35849, MGI:107382

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory