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Myo1a Gene Detail
 Symbol
Name
ID
Myo1a
myosin IA
MGI:107732


Nomenclature History
Synonyms BBM-I, brush border myosin 1, Myhl
Genetic Map
Chromosome 10
70.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr10:127142312-127157994 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Myo1a ± 2 cM)
Protein SuperFamily: myosin I
TreeFam: TF312960
Sequences
Representative Sequences Length Strain/Species Flank
genomic 432516 NCBI Gene Model | MGI Sequence Detail 15683 C57BL/6J ± Kb
transcript NM_001081219 RefSeq | MGI Sequence Detail 3353 C57BL/6
polypeptide O88329 UniProt | EBI | MGI Sequence Detail 1043 Not Applicable
For the selected sequences
All sequences(15)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Homozygous null mice display abnormal small intestine brush border morphology, but have normal hearing.
Polymorphisms RFLP(1) SNPs within 2kb(100 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(16)
Process cell projection organization, microvillus assembly...
Component apical plasma membrane, basal plasma membrane...
Function actin binding, ATP binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (2 records)
Data Summary: Assays (2)    Results (5)    Tissues (5)
Theiler Stages: 22,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   5
cDNA source data(12)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(14) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000025401
DoTS DT.55205307, DT.91576577
UniGene 90450
DFCI TC1606232, TC1608124
NIA Mouse Gene Index U012157
Entrez Gene 432516
International Mouse Knockout Project Status Myo1a
Protein
domains
InterPro ID Description
IPR000048 IQ calmodulin-binding region
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
Graphical View of Protein Domain Structure
References
(Earliest) J:4139 Sherr EH et al., "Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family." J Cell Biol 1993 Mar;120(6):1405-16
(Latest) J:134720 McConnell RE et al., "Myosin-1a powers the sliding of apical membrane along microvillar actin bundles." J Cell Biol 2007 May 21;177(4):671-81
All references(9)
Other
accession IDs
MGD-MRK-36308, MGI:1338019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory