Symbol
Name
ID
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Synonyms
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Chuk1, IkappaB kinase alpha, IKK 1, IKK alpha, IKK-1, IKK-alpha, IKK[a], IKK1, IKKalpha
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(39)
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Alleles
and
phenotypes
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All alleles(28) :
Targeted, knock-out(3)
Targeted, other(7)
Gene trapped(18)
| Homozygotes for targeted null mutations die neonataly and exhibit thickened, taut, adhesive skin that prevents appendages from protruding from the trunk, absence of whiskers, skeletal abnormalities, and closed esophagus. |
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Polymorphisms
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All PCR and RFLP(2) :
PCR(1)
RFLP(1)
SNPs within 2kb(160 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (15 records)
Data Summary:
Assays (2)
Results (50)
Tissues (48)
Images (1)
Theiler Stages: 10,18,23,25,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
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46 |
| |
Northern blot |
1 |
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4 |
cDNA source data(19)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
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All nucleic(24)
cDNA(22)
Primer pair(2)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:26193
Mock BA et al.,
"CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19."
Genomics 1995 May 20;27(2):348-51
(Latest)
J:155777
Pawlowski TL et al.,
"Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice."
Genomics 2009 Sep;94(3):188-95
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All references(85)
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Other
accession IDs
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MGD-MRK-16258, MGI:2147493
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Analysis Tools
MGI BioMart
