Symbol
Name
ID
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Synonyms
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G972R, IRS-1
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(26)
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Alleles
and
phenotypes
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All alleles(5) :
Targeted, knock-out(2)
Targeted, other(3)
| Homozygotes for targeted null mutations exhibit 50 percent reductions in body weights at birth and at 4 months of age, impaired glucose tolerance, and mild insulin and IGF-1 resistance. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (2)
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Polymorphisms
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SNPs within 2kb(353 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (9 records)
Data Summary:
Assays (5)
Results (56)
Tissues (50)
Images (4)
Theiler Stages: 4,10,18,23,25,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
3 |
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50 |
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Northern blot |
2 |
|
6 |
cDNA source data(10)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
|
All nucleic(21)
Genomic(7)
cDNA(10)
Primer pair(3)
Other(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:4645
Keller SR et al.,
"The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning."
Biochim Biophys Acta 1993 Mar 20;1172(3):323-6
(Latest)
J:152946
Sferruzzi-Perri AN et al.,
"Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice."
Biol Reprod 2009 Jul;81(1):207-21
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All references(114)
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Other
accession IDs
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MGD-MRK-16223
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