Yaa Cytogenetic Marker Detail
Symbol
Name
ID
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Synonyms
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Tp(X;Y)1Ekw
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Genetic Map
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Chromosome Y
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Syntenic
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Mapping data(
1)
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Alleles
and
phenotypes
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All alleles(1) :
Spontaneous(1)
| Mutant males have accelerated autoimmunity, lymphoproliferation, splenomegaly, hemolytic anemia, hypergammaglobulinemia and glomerulonephritis. The syndrome is strain-dependent, requiring presence of certain autosomal allelic combinations. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (1)
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Other database
links
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References
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(Earliest)
J:6235
Murphy ED et al.,
"A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation."
Arthritis Rheum 1979 Nov;22(11):1188-94
(Latest)
J:148718
Maeda K et al.,
"Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals."
Blood 2009 May 7;113(19):4534-40
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All references(71)
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Other
accession IDs
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MGD-MRK-15837
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