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Wnt4 Gene Detail
 Symbol
Name
ID
Wnt4
wingless-related MMTV integration site 4
MGI:98957


Nomenclature History
Synonyms Wnt-4
Genetic Map
Chromosome 4
Syntenic
 
Mapping data( 1)
Sequence Map
Chr4:136833404-136855641 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009828 VEGA Gene Model | MGI Sequence Detail 22238 C57BL/6J ± Kb
transcript NM_009523 RefSeq | MGI Sequence Detail 1101 C57BL/6
polypeptide P22724 UniProt | EBI | MGI Sequence Detail 351 Not Applicable
For the selected sequences
All sequences(23)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(1) Targeted, other(4)
Homozygous mutants exhibit impaired development of the kidney, pituitary gland, and female reproductive system. Mutants die within 24 hours of birth.
Polymorphisms SNPs within 2kb(101 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process anatomical structure development, cell differentiation...
Component extracellular region, proteinaceous extracellular matrix...
Function protein binding, receptor binding...
External Resources: FuncBase
Expression Literature Summary: (121 records)
Data Summary: Assays (25)    Results (205)    Tissues (157)    Images (61)
Theiler Stages: 1,2,3,4,5,8,9,11,13,15,17,18,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 11   41
      RNA in situ 13   162
      RNase protection 1   2
cDNA source data(34)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(57) Genomic(3) cDNA(37) Primer pair(12) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000036856, ENSMUSG00000073745
DoTS DT.484192, DT.97354380
Consensus CDS Project CCDS18815.1
UniGene 20355
DFCI TC1599329
NIA Mouse Gene Index U004979, U004980
Entrez Gene 22417
VEGA Gene Model OTTMUSG00000009828
International Mouse Knockout Project Status Wnt4
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR009142 Wnt-4 protein
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:10971 Gavin BJ et al., "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development." Genes Dev 1990 Dec;4(12B):2319-32
(Latest) J:156022 Anderson KR et al., "Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development." BMC Dev Biol 2009;9():65
All references(153)
Other
accession IDs
MGD-MRK-15442, MGD-MRK-15452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory