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Wnt3 Gene Detail
 Symbol
Name
ID
Wnt3
wingless-related MMTV integration site 3
MGI:98955


Nomenclature History
Synonyms Int-4, Wnt-3
Genetic Map
Chromosome 11
63.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 37)

Sequence Map
Chr11:103635464-103679271 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt3 ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003018 VEGA Gene Model | MGI Sequence Detail 43808 C57BL/6J ± Kb
transcript NM_009521 RefSeq | MGI Sequence Detail 3115 C57BL/6
polypeptide P17553 UniProt | EBI | MGI Sequence Detail 355 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(2)
Homozygous mutants develop to the egg cylinder stage, but fail to form a primitive streak, mesoderm, or node, and die by embryonic day 10.5.
Polymorphisms RFLP(7) SNPs within 2kb(274 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process anatomical structure formation involved in morphogenesis, anterior/posterior pattern formation...
Component extracellular region, proteinaceous extracellular matrix...
Function protein binding, receptor binding...
External Resources: FuncBase
Expression Literature Summary: (91 records)
Data Summary: Assays (25)    Results (387)    Tissues (202)    Images (30)
Theiler Stages: 1,2,3,4,5,8,9,11,13,15,16,17,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 11   131
      RNA in situ 11   248
      Immunohistochemistry 1   5
      Northern blot 1   1
      RNase protection 1   2
cDNA source data(20)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(60) Genomic(21) cDNA(22) Primer pair(13) Other(4) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000000125
DoTS DT.110547418, DT.40140176
Consensus CDS Project CCDS25523.1
UniGene 159091
DFCI TC1586202
NIA Mouse Gene Index U013423
Entrez Gene 22415
VEGA Gene Model OTTMUSG00000003018
International Mouse Knockout Project Status Wnt3
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR009141 Wnt-3 protein
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:9831 Buchberg AM et al., "A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human." Genetics 1989 May;122(1):153-61
(Latest) J:155223 Suomalainen M et al., "Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells." Dev Dyn 2009 Oct 5;239(1):364-372
All references(137)
Other
accession IDs
MGD-MRK-11421, MGD-MRK-15440, MGD-MRK-15450

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory