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Wnt1 Gene Detail
 Symbol
Name
ID
Wnt1
wingless-related MMTV integration site 1
MGI:98953

Nomenclature History
Synonyms Int-1, Wnt-1
Genetic Map
Chromosome 15
56.8 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM
 
Mapping data( 50)

Sequence Map
Chr15:98620288-98624268 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt1 ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020981 VEGA Gene Model | MGI Sequence Detail 3981 C57BL/6J ± Kb
transcript NM_021279 RefSeq | MGI Sequence Detail 2371 C57BL/6
polypeptide P04426 UniProt | EBI | MGI Sequence Detail 370 Not Applicable
For the selected sequences
All sequences(14)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(3) Spontaneous(1)
In mild form, homozygotes have ataxia and hypertonia, with malformation of anterior cerebellum, deep midline fissure, and impaired fertility. In the severe form, there is virtually no midbrain and cerebellum and mutants die within hours of birth.
Polymorphisms All PCR and RFLP(14) : PCR(2) RFLP(12) SNPs within 2kb(54 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell-cell signaling, diencephalon development...
Component extracellular region, proteinaceous extracellular matrix...
Function protein binding, receptor binding...
External Resources: FuncBase
Expression Literature Summary: (199 records)
Data Summary: Assays (69)    Results (618)    Tissues (272)    Images (132)
Theiler Stages: 1,2,3,4,5,8,9,11,12,13,14,15,16,17,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 8   122
      RNA in situ 53   445
      Immunohistochemistry 1   4
      Northern blot 6   45
      RNase protection 1   2
cDNA source data(26)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(84) Genomic(10) cDNA(31) Primer pair(11) Other(32) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022997
DoTS DT.40139855
Consensus CDS Project CCDS27807.1
UniGene 1123
DFCI TC1589053
NIA Mouse Gene Index U016627
Entrez Gene 22408
VEGA Gene Model OTTMUSG00000020981
International Mouse Knockout Project Status Wnt1
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR009139 Wnt-1 protein
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:15063 Lane PW, "Swaying" Mouse News Lett 1967;36():40
(Latest) J:155074 Agalliu D et al., "Motor neurons with axial muscle projections specified by Wnt4/5 signaling." Neuron 2009 Mar 12;61(5):708-20
All references(330)
Other
accession IDs 		MGD-MRK-11418, MGD-MRK-14669, MGD-MRK-15438, MGD-MRK-15448
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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