About   Help   FAQ
Wap Gene Detail
 Symbol
Name
ID
Wap
whey acidic protein
MGI:98943


Nomenclature History
Genetic Map
Chromosome 11
0.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr11:6535485-6538640 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
dog, domestic; pig, domestic; rabbit, European; rat    (Mammalian Orthology)
Protein SuperFamily: four-disulfide core domain protein, WAP type
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005118 VEGA Gene Model | MGI Sequence Detail 3156 C57BL/6J ± Kb
transcript NM_011709 RefSeq | MGI Sequence Detail 562 C57BL/6
polypeptide P01173 UniProt | EBI | MGI Sequence Detail 134 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Homozygous mutants are phenotypically normal and fertile. Functional differentiation of mammary epithelium is normal and dams produce milk, but pups thrive poorly on milk lacking whey acidic protein. A normal variant determines a one amino acid change in WAP protein in YBR versus other strains.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(15 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(4)
Component extracellular region
Function peptidase inhibitor activity
External Resources: MouseFunc
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23,28
  Assay Type Assays   Results
      RT-PCR 1   46
cDNA source data(257)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(266) Genomic(5) cDNA(257) Primer pair(1) Other(3)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000000381
DoTS DT.55191380, DT.99841184
UniGene 268094
NIA Mouse Gene Index U032498
Entrez Gene 22373
VEGA Gene Model OTTMUSG00000005118
International Mouse Knockout Project Status Wap
Protein
domains
InterPro ID Description
IPR008197 Whey acidic protein, 4-disulphide core
Graphical View of Protein Domain Structure
References
(Earliest) J:6634 Piletz JE et al., "Biochemical characterization of a novel whey protein from murine milk." J Biol Chem 1981 Nov 25;256(22):11509-16
(Latest) J:148684 Creamer BA et al., "Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging." Genesis 2009 Apr;47(4):234-45
All references(30)
Other
accession IDs
MGD-MRK-15427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/20/2009
MGI_4.31
Web browser compatibility
The Jackson Laboratory