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Trp53 Gene Detail
 Symbol
Name
ID
Trp53
transformation related protein 53
MGI:98834

Nomenclature History
Synonyms p53
Genetic Map
Chromosome 11
39.0 cM, cytoband B2-C
Detailed Genetic Map ± 1 cM
 
Mapping data( 41)

Sequence Map
Chr11:69393861-69405375 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; gorilla; hamster, Chinese; pig, domestic; rat; hamster, golden    (Mammalian Orthology)
Comparative Map (Mouse/Human Trp53 ± 2 cM)
Protein SuperFamily: tumor suppressor p53
TreeFam: TF106101
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005982 VEGA Gene Model | MGI Sequence Detail 11515 C57BL/6J ± Kb
transcript NM_001127233 RefSeq | MGI Sequence Detail 1877 C57BL/6
polypeptide P02340 UniProt | EBI | MGI Sequence Detail 387 Not Applicable
For the selected sequences
All sequences(70)
Alleles
and
phenotypes 		All alleles(208) : Targeted, knock-out(9) Targeted, other(34) Gene trapped(163) Chemically induced(2)
Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes.
Associated Human Diseases (11)   Alleles Annotated to Human Diseases (6)   Phenotype Images (2)  
Polymorphisms All PCR and RFLP(10) : PCR(3) RFLP(7) SNPs within 2kb(77 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(115)
Process apoptosis, B cell lineage commitment...
Component cytoplasm, cytosol...
Function chromatin binding, DNA binding...
External Resources: MouseFunc
Expression Literature Summary: (95 records)
Data Summary: Assays (27)    Results (293)    Tissues (162)    Images (26)
Theiler Stages: 1,2,3,4,5,10,12,14,16,17,18,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 6   20
      RT-PCR 6   117
      RNA in situ 6   94
      Immunohistochemistry 2   8
      Northern blot 7   54
cDNA source data(125)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(161) Genomic(15) cDNA(134) Primer pair(9) Other(3) Antibodies(7)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000059552
DoTS DT.101385652, DT.101385654, DT.101736546, DT.492736
UniGene 222
PDB 1HU8, 2GEQ, 2IOI, 2IOM, 2IOO, 2P52, 3EXJ, 3EXL
DFCI TC1575834, TC1591213, TC1715697
NIA Mouse Gene Index U012823, U272134
Entrez Gene 22059
VEGA Gene Model OTTMUSG00000005982
International Mouse Knockout Project Status Trp53
Protein
domains
InterPro ID Description
IPR002117 p53 tumour antigen
IPR008967 p53-like transcription factor, DNA-binding
IPR010991 p53, tetramerisation
IPR011615 p53, DNA-binding
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
IPR013872 p53 transactivation domain
IPR015551 Cellular tumour antigen p53
Graphical View of Protein Domain Structure
References
(Earliest) J:6969 Oren M et al., "Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen." Proc Natl Acad Sci U S A 1983 Jan;80(1):56-9
(Latest) J:153954 Xing D et al., "A role for BRCA1 in uterine leiomyosarcoma." Cancer Res 2009 Nov 1;69(21):8231-5
All references(1504)
Other
accession IDs 		MGD-MRK-15247, MGI:3584375, MGI:3584378, MGI:3584379
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory