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Tgfb2 Gene Detail
 Symbol
Name
ID
Tgfb2
transforming growth factor, beta 2
MGI:98726

Nomenclature History
Synonyms Tgf-beta2, Tgfb-2
Genetic Map
Chromosome 1
101.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 16)

Sequence Map
Chr1:188447529-188529868 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Tgfb2 ± 2 cM)
Protein SuperFamily: transforming growth factor-beta
TreeFam: TF318514
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000039239 Ensembl Gene Model | MGI Sequence Detail 82340 C57BL/6J ± Kb
transcript NM_009367 RefSeq | MGI Sequence Detail 4725 C57BL/6
polypeptide P27090 UniProt | EBI | MGI Sequence Detail 414 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes 		All alleles(1) : Targeted, knock-out(1)
Homozygotes for a targeted null mutation exhibit defects of the heart, lungs, skull, limbs, spinal column, eyes, inner ears, and urogenital system, and perinatal mortality. Heterozygotes show abnormalities of the Cowpers' gland and intestinal mucosa.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(1) SNPs within 2kb(237 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(30)
Process activation-induced cell death of T cells, axon guidance...
Component axon, cell soma...
Function growth factor activity, protein binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (105 records)
Data Summary: Assays (33)    Results (347)    Tissues (257)    Images (136)
Theiler Stages: 1,2,3,4,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 7   21
      RNA in situ 13   169
      Immunohistochemistry 5   114
      Northern blot 7   41
      RNase protection 1   2
cDNA source data(94)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(110) Genomic(1) cDNA(96) Primer pair(7) Other(6) Antibodies(5)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000039239
DoTS DT.101370722, DT.110895060, DT.91311064
UniGene 18213
DFCI TC1574828, TC1632269, TC1655922
NIA Mouse Gene Index U022179
Entrez Gene 21808
International Mouse Knockout Project Status Tgfb2
Protein
domains
InterPro ID Description
IPR001111 Transforming growth factor beta (TGFb), N-terminal
IPR001839 Transforming growth factor beta
IPR003911 Transforming growth factor beta TGFb
IPR003940 Transforming growth factor, beta 2
IPR015615 Transforming growth factor-beta-related
IPR016319 Transforming growth factor-beta
IPR017948 Transforming growth factor beta, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:9636 Barton DE et al., "Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family." Oncogene Res 1988;3(4):323-31
(Latest) J:152572 Iwao K et al., "Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling." J Clin Invest 2009 Jul;119(7):1997-2008
All references(171)
Other
accession IDs 		MGD-MRK-15065, MGD-MRK-15068, MGI:2138633
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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