About   Help   FAQ
Tcf7 Gene Detail
 Symbol
Name
ID
Tcf7
transcription factor 7, T-cell specific
MGI:98507


Nomenclature History
Synonyms T cell factor-1, T-cell factor 1, TCF-1, Tcf1
Genetic Map
Chromosome 11
28.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr11:52065873-52096516 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Tcf7 ± 2 cM)
TreeFam: TF318448
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005622 VEGA Gene Model | MGI Sequence Detail 30644 C57BL/6J ± Kb
transcript NM_009331 RefSeq | MGI Sequence Detail 2238 C57BL/6
polypeptide Q00417 UniProt | EBI | MGI Sequence Detail 419 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(2) Gene trapped(4)
Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery.
Polymorphisms RFLP(2) SNPs within 2kb(232 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process embryonic digestive tract morphogenesis, embryonic genitalia morphogenesis...
Component nucleus
Function DNA binding, transcription factor activity...
External Resources: FuncBase
Expression Literature Summary: (36 records)
Data Summary: Assays (11)    Results (149)    Tissues (135)    Images (19)
Theiler Stages: 2,3,4,5,17,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 5   25
      RNA in situ 6   124
cDNA source data(74)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(87) Genomic(2) cDNA(77) Primer pair(7) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000000782
DoTS DT.101392463, DT.101392464, DT.101392466, DT.110545866, DT.492238
Consensus CDS Project CCDS24670.1
UniGene 31630
DFCI TC1581742, TC1631714, TC1683384
NIA Mouse Gene Index U032752
Entrez Gene 21414
VEGA Gene Model OTTMUSG00000005622
International Mouse Knockout Project Status Tcf7
Protein
domains
InterPro ID Description
IPR000910 High mobility group, HMG1/HMG2
IPR009071 High mobility group, superfamily
IPR013558 CTNNB1 binding, N-teminal
Graphical View of Protein Domain Structure
References
(Earliest) J:11147 Oosterwegel M et al., "Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers." J Exp Med 1991 May 1;173(5):1133-42
(Latest) J:155223 Suomalainen M et al., "Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells." Dev Dyn 2009 Oct 5;239(1):364-372
All references(65)
Other
accession IDs
MGD-MRK-14759, MGI:2144188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory