Symbol
Name
ID
|
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Synonyms
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T cell factor-1, T-cell factor 1, TCF-1, Tcf1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(33)
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Alleles
and
phenotypes
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All alleles(6) :
Targeted, knock-out(2)
Gene trapped(4)
| Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(232 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (34 records)
Data Summary:
Assays (10)
Results (141)
Tissues (127)
Images (17)
Theiler Stages: 2,3,4,5,17,19,20,21,22,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
5 |
|
25 |
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RNA in situ |
5 |
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116 |
cDNA source data(72)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(85)
Genomic(2)
cDNA(75)
Primer pair(7)
Other(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000910 |
High mobility group, HMG1/HMG2 |
| IPR009071 |
High mobility group, superfamily |
| IPR013558 |
CTNNB1 binding, N-teminal |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:11147
Oosterwegel M et al.,
"Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers."
J Exp Med 1991 May 1;173(5):1133-42
(Latest)
J:152395
Kovalovsky D et al.,
"Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling."
J Immunol 2009 Sep 15;183(6):3873-84
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All references(63)
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Other
accession IDs
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MGD-MRK-14759, MGI:2144188
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