About   Help   FAQ
Tour our new Quick Search
T Gene Detail
 Symbol
Name
ID
T
brachyury
MGI:98472

Nomenclature History
Synonyms Bra, cou, Low, low ratio, Lr, me75, T1, Tl2, Tl3
Genetic Map
Chromosome 17
4.02 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 105)

Sequence Map
Chr17:8627288-8635361 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human T ± 2 cM)
Protein SuperFamily: mouse gene T protein
TreeFam: TF106341
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000026263 VEGA Gene Model | MGI Sequence Detail 8074 C57BL/6J ± Kb
transcript NM_009309 RefSeq | MGI Sequence Detail 2046 C57BL/6
polypeptide P20293 UniProt | EBI | MGI Sequence Detail 436 Not Applicable
For the selected sequences
All sequences(13)
Alleles
and
phenotypes 		All alleles(38) : Transgenic(1) Spontaneous(16) Chemically induced(10) Radiation induced(16)
Homozygotes exhibit defects in notochord differentiation and mesoderm formation, lack a trunk and tail, and die around embryonic day 10. Heterozygotes have a shortened tail and abnormal sacral vertebrae. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of XY mice.
Phenotype Images (3)  
Polymorphisms RFLP(5) SNPs within 2kb(60 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(21)
Process anatomical structure morphogenesis, anterior/posterior pattern formation...
Component cytoplasm, nucleus...
Function DNA binding, protein binding...
External Resources: MouseFunc
Expression Literature Summary: (333 records)
Data Summary: Assays (88)    Results (616)    Tissues (185)    Images (221)
Theiler Stages: 2,3,4,5,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,25,28
  Assay Type Assays   Results
      Western blot 2   2
      RT-PCR 14   132
      RNA in situ 64   392
      Immunohistochemistry 6   71
      Northern blot 2   19
cDNA source data(31)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(74) Genomic(4) cDNA(38) Primer pair(14) Other(18) Antibodies(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000062327
DoTS DT.489914
UniGene 913
DFCI TC1586132
NIA Mouse Gene Index U017472
Entrez Gene 20997
VEGA Gene Model OTTMUSG00000026263
International Mouse Knockout Project Status T
Protein
domains
InterPro ID Description
IPR001699 Transcription factor, T-box
IPR002070 Transcription factor, Brachyury
IPR008967 p53-like transcription factor, DNA-binding
IPR018186 Transcription factor, T-box, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:14909 Dobrovolskaia-Zavadskaia N, "Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable"" C R Seances Soc Biol Fil 1927;97():114-16
(Latest) J:153642 Vlangos CN et al., "Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis." Dev Biol 2009 Oct 15;334(2):418-28
All references(526)
Other
accession IDs 		MGD-MRK-11865, MGD-MRK-11883, MGD-MRK-14695, MGD-MRK-2096, MGI:2152887, MGI:2152888
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory