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Sod2 Gene Detail
 Symbol
Name
ID
Sod2
superoxide dismutase 2, mitochondrial
MGI:98352

Nomenclature History
Synonyms manganese SOD, manganese superoxide dismutase, MGC:6144, MnSOD, Sod-2
Genetic Map
Chromosome 17
7.6 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 18)

Sequence Map
Chr17:13200848-13208219 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Sod2 ± 2 cM)
Protein SuperFamily: superoxide dismutase, Mn/Fe specific
TreeFam: TF105132
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000006818 Ensembl Gene Model | MGI Sequence Detail 7372 C57BL/6J ± Kb
transcript NM_013671 RefSeq | MGI Sequence Detail 3824 C57BL/6
polypeptide P09671 UniProt | EBI | MGI Sequence Detail 222 Not Applicable
For the selected sequences
All sequences(45)
Alleles
and
phenotypes 		All alleles(11) : Targeted, knock-out(3) Targeted, other(1) Gene trapped(7)
Mutations affect mitochondrial function. Null homozygotes die early with cardiomyopathy, tissue lipid accumulation, neurodegeneration, motor problems and/or metabolic acidosis depending on strain background. Heterozygotes show mitochondria and apoptosis defects with age.
Associated Human Diseases (3)   Alleles Annotated to Human Diseases (1)   Phenotype Images (2)  
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(46 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(60)
Process age-dependent response to oxidative stress, apoptosis...
Component mitochondrial inner membrane, mitochondrion...
Function manganese ion binding, metal ion binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (10 records)
Data Summary: Assays (5)    Results (14)    Tissues (6)
Theiler Stages: 4,26,28
  Assay Type Assays   Results
      Western blot 1   6
      RT-PCR 4   8
cDNA source data(93)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(102) Genomic(3) cDNA(96) Primer pair(2) Other(1) Antibodies(1)
Microarray probesets(4)
Pathways
removal of superoxide radicals
Other database
links
EC 1.15.1.1
Ensembl Gene Model ENSMUSG00000006818
DoTS DT.101264414, DT.101405704, DT.486387, DT.99844676
UniGene 290876
DFCI TC1572750, TC1648584, TC1696074
Entrez Gene 20656
International Mouse Knockout Project Status Sod2
Protein
domains
InterPro ID Description
IPR001189 Manganese/iron superoxide dismutase
IPR019831 Manganese/iron superoxide dismutase, N-terminal
IPR019832 Manganese/iron superoxide dismutase, C-terminal
IPR019833 Manganese/iron superoxide dismutase, binding site
Graphical View of Protein Domain Structure
References
(Earliest) J:5406 Creagan R et al., "Chromosome assignments of genes in man using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol oxidase-B, tetrameric) to chromosome 6." Humangenetik 1973 Dec 10;20(3):203-9
(Latest) J:153687 Hoehn KL et al., "Insulin resistance is a cellular antioxidant defense mechanism." Proc Natl Acad Sci U S A 2009 Oct 20;106(42):17787-92
All references(147)
Other
accession IDs 		MGD-MRK-14484, MGD-MRK-14486
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory