Symbol
Name
ID
|
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Synonyms
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SCD, Scd-1, stearoyl-CoA desaturase
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(37)
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Alleles
and
phenotypes
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All alleles(13) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(6)
Spontaneous(4)
Chemically induced(1)
| Homozygotes for targeted and spontaneous mutations exhibit alopecia, scaly skin, sebaceous gland hypoplasia, impaired ocular lubrication and synthesis and storage of triglycerides, higher lipid oxidation, reduced growth, and lower fertility in females. |
Phenotype Images (2)
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Polymorphisms
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RFLP(4)
SNPs within 2kb(73 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (8 records)
Data Summary:
Assays (7)
Results (16)
Tissues (5)
Images (4)
Theiler Stages: 22,23,28
| |
Assay Type |
Assays |
|
Results |
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RT-PCR |
2 |
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6 |
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RNA in situ |
1 |
|
1 |
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Northern blot |
4 |
|
9 |
cDNA source data(25)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(38)
Genomic(7)
cDNA(28)
Primer pair(3)
Microarray probesets(6)
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Pathways
|
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR001522 |
Fatty acid desaturase, type 1, C-terminal |
| IPR005804 |
Fatty acid desaturase, type 1 |
| IPR015876 |
Fatty acid desaturase, type 1, core |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:13143
Gates AH et al.,
"Hereditary absence of sebaceous glands in the mouse."
Science 1965;148():1471-1473
(Latest)
J:152631
Sampath H et al.,
"Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity."
J Biol Chem 2009 Jul 24;284(30):19961-73
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All references(95)
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Other
accession IDs
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MGD-MRK-1014, MGD-MRK-14305, MGD-MRK-14307, MGI:2147455, MGI:2147495, MGI:87858
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