Symbol
Name
ID
|
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Synonyms
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Rag-1
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
|
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Sequences
|
All sequences(19)
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Alleles
and
phenotypes
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All alleles(8) :
Targeted, knock-out(2)
Targeted, other(5)
Chemically induced(1)
| Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination. |
Associated Human Diseases (3)
Alleles Annotated to Human Diseases (1)
Phenotype Images (1)
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Polymorphisms
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RFLP(4)
SNPs within 2kb(115 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (16 records)
Data Summary:
Assays (18)
Results (114)
Tissues (67)
Images (1)
Theiler Stages: 10,13,15,16,18,19,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
|
Results |
| |
RT-PCR |
15 |
|
103 |
| |
Northern blot |
3 |
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11 |
cDNA source data(24)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
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All nucleic(45)
Genomic(13)
cDNA(26)
Primer pair(5)
Other(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR001841 |
Zinc finger, RING-type |
| IPR013087 |
Zinc finger, C2H2-type/integrase, DNA-binding |
| IPR015880 |
Zinc finger, C2H2-like |
| IPR017907 |
Zinc finger, RING-type, conserved site |
| IPR018957 |
Zinc finger, C3HC4 RING-type |
| IPR019485 |
Zinc finger, V(D)J recombination-activating protein 1 |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:10163
Schatz DG et al.,
"The V(D)J recombination activating gene, RAG-1."
Cell 1989 Dec 22;59(6):1035-48
(Latest)
J:154208
Schymeinsky J et al.,
"A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo."
Blood 2009 Nov 5;114(19):4209-20
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All references(521)
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Other
accession IDs
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MGD-MRK-13753, MGD-MRK-13755
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