Symbol
Name
ID
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Synonyms
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CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(52)
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Alleles
and
phenotypes
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All alleles(25) :
Targeted, knock-out(10)
Targeted, other(12)
Spontaneous(3)
| Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (2)
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Polymorphisms
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RFLP(27)
SNPs within 2kb(77 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (7 records)
Data Summary:
Assays (3)
Results (50)
Tissues (44)
Images (17)
Theiler Stages: 9,11,13,15,21,22,24,28
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Assay Type |
Assays |
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Results |
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RNA in situ |
3 |
|
50 |
cDNA source data(28)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(57)
Genomic(14)
cDNA(33)
Primer pair(1)
Other(9)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000817 |
Prion protein |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:5082
Dickinson AG et al.,
"Identification of a gene which controls the incubation period of some strains of scrapie agent in mice."
J Comp Pathol 1968 Jul;78(3):293-9
(Latest)
J:154107
Arsac JN et al.,
"Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype."
PLoS One 2009;4(10):e7300
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All references(349)
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Other
accession IDs
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MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768
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