Symbol
Name
ID
|
|
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Synonyms
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Nr1c3, PPAR-gamma, Ppar-gamma2, PPARgamma, PPARgamma2
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(41)
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Alleles
and
phenotypes
|
All alleles(25) :
Targeted, knock-out(7)
Targeted, other(18)
| Homozygotes for targeted null mutations exhibit lethality due to placental defects. Heterozygotes show greater B cell proliferation, enhanced leptin secretion, and resistance to diet-induced adipocyte hypertrophy and insulin resistance. |
Associated Human Diseases (3)
Alleles Annotated to Human Diseases (4)
Phenotype Images (6)
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Polymorphisms
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RFLP(2)
SNPs within 2kb(308 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (26 records)
Data Summary:
Assays (7)
Results (138)
Tissues (110)
Images (13)
Theiler Stages: 15,17,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
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Results |
| |
RT-PCR |
2 |
|
14 |
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RNA in situ |
1 |
|
93 |
| |
Northern blot |
4 |
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31 |
cDNA source data(31)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
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All nucleic(44)
Genomic(7)
cDNA(32)
Primer pair(3)
Other(2)
Microarray probesets(2)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR000536 |
Nuclear hormone receptor, ligand-binding, core |
| IPR001628 |
Zinc finger, nuclear hormone receptor-type |
| IPR001723 |
Steroid hormone receptor |
| IPR003074 |
Peroxisome proliferator-activated receptor |
| IPR003077 |
Peroxisome proliferator-activated receptor, gamma |
| IPR008946 |
Nuclear hormone receptor, ligand-binding |
| IPR013088 |
Zinc finger, NHR/GATA-type |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:15412
Chen F et al.,
"Identification of two mPPAR related receptors and evidence for the existence of five subfamily members."
Biochem Biophys Res Commun 1993 Oct 29;196(2):671-7
(Latest)
J:153891
Tsai YS et al.,
"Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity."
Mol Endocrinol 2009 Nov;23(11):1787-98
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All references(236)
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Other
accession IDs
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MGD-MRK-13589
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