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Pnlip Gene Detail
 Symbol
Name
ID
Pnlip
pancreatic lipase
MGI:97722

Nomenclature History
Synonyms 1810007A24Rik, MGC:74173, pancreatic triglyceride lipase, PTL
Genetic Map
Chromosome 19
29.0 cM, cytoband D3
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr19:58744855-58756276 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pnlip ± 2 cM)
Protein SuperFamily: lipoprotein lipase, LIPH type
TreeFam: TF324997
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000046008 Ensembl Gene Model | MGI Sequence Detail 11422 C57BL/6J ± Kb
transcript NM_026925 RefSeq | MGI Sequence Detail 1515 -
polypeptide NP_081201 RefSeq | MGI Sequence Detail 465 -
For the selected sequences
All sequences(12)
Alleles
and
phenotypes 		All alleles(1) : Targeted, knock-out(1)
Homozygous null mice show impaired dietary cholesterol, triglyceride and retinyl ester absorption, resistance to diet-induced obesity, and insulin resistance.
Polymorphisms RFLP(2) SNPs within 2kb(40 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(3)
Process intestinal cholesterol absorption, lipid catabolic process...
Function hydrolase activity
External Resources: MouseFunc
Expression cDNA source data(332)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(335) cDNA(334) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000046008
DoTS DT.526226
UniGene 20407
DFCI TC1571871
NIA Mouse Gene Index U052115
Entrez Gene 69060
International Mouse Knockout Project Status Pnlip
Protein
domains
InterPro ID Description
IPR000734 Lipase
IPR001024 Lipoxygenase, LH2
IPR002331 Pancreatic lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
References
(Earliest) J:43376 Grusby MJ et al., "Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase." Cell 1990 Feb 9;60(3):451-9
(Latest) J:124658 Gilham D et al., "Carboxyl ester lipase deficiency exacerbates dietary lipid absorption abnormalities and resistance to diet-induced obesity in pancreatic triglyceride lipase knockout mice." J Biol Chem 2007 Aug 24;282(34):24642-9
All references(12)
Other
accession IDs 		MGD-MRK-13544, MGI:1916310
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
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