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Plcg1 Gene Detail
 Symbol
Name
ID
Plcg1
phospholipase C, gamma 1
MGI:97615

Nomenclature History
Synonyms Cded, Plc-1, Plc-gamma1, Plcg-1
Genetic Map
Chromosome 2
92.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 11)

Sequence Map
Chr2:160557036-160601496 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Plcg1 ± 2 cM)
Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma
TreeFam: TF313216
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000001177 VEGA Gene Model | MGI Sequence Detail 44461 C57BL/6J ± Kb
transcript NM_021280 RefSeq | MGI Sequence Detail 4435 C57BL/6
polypeptide Q62077 UniProt | EBI | MGI Sequence Detail 1302 Not Applicable
For the selected sequences
All sequences(37)
Alleles
and
phenotypes 		All alleles(7) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(4)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(150 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process in utero embryonic development, intracellular signaling cascade...
Component cytoplasm
Function calcium ion binding, glutamate receptor binding...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Assays (3)    Results (70)    Tissues (65)    Images (2)
Theiler Stages: 2,3,4,5,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 1   9
      RT-PCR 2   61
cDNA source data(14)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(28) Genomic(8) cDNA(14) Primer pair(4) Other(2) Antibodies(1)
Microarray probesets(2)
Pathways
phospholipases
Other database
links
EC 3.1.4.11
Ensembl Gene Model ENSMUSG00000016933
DoTS DT.101735503, DT.110744762, DT.110744819, DT.87029466, DT.87055455, DT.94333575, DT.97409329
Consensus CDS Project CCDS16996.1
DFCI TC1579879, TC1610670, TC1665293
NIA Mouse Gene Index U002767
Entrez Gene 18803
VEGA Gene Model OTTMUSG00000001177
International Mouse Knockout Project Status Plcg1
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR000980 SH2 motif
IPR001192 Phospholipase C, phosphoinositol-specific, C-terminal (PLC)
IPR001452 Src homology-3 domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR011993 Pleckstrin homology-type
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR018029 C2 membrane targeting protein
IPR018247 EF-Hand 1, calcium-binding site
IPR018249 EF-HAND 2
IPR020473 Src homology-3, region
Graphical View of Protein Domain Structure
References
(Earliest) J:30483 Hempel WM et al., "Expression of phospholipase C isozymes by murine B lymphocytes." J Immunol 1991 Jun 1;146(11):3713-20
(Latest) J:154601 Seuntjens E et al., "Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors." Nat Neurosci 2009 Nov;12(11):1373-80
All references(48)
Other
accession IDs 		MGD-MRK-13350, MGD-MRK-13353, MGD-MRK-13355, MGI:1329022, MGI:2139113
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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