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Pklr Gene Detail
 Symbol
Name
ID
Pklr
pyruvate kinase liver and red blood cell
MGI:97604

Nomenclature History
Synonyms Pk-1, Pk1, R-PK
Genetic Map
Chromosome 3
44.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr3:88940064-88950706 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pklr ± 2 cM)
Protein SuperFamily: pyruvate kinase
TreeFam: TF300390
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000017504 VEGA Gene Model | MGI Sequence Detail 10643 C57BL/6J ± Kb
transcript NM_013631 RefSeq | MGI Sequence Detail 2787 C57BL/6
polypeptide P53657 UniProt | EBI | MGI Sequence Detail 574 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(2) : Spontaneous(2)
Mice homozygous for loss of function mutations in this gene suffer from hemolytic anemia. This is also a candidate gene for malaria resistance QTL Char4.
Polymorphisms RFLP(1) SNPs within 2kb(61 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process glycolysis, response to other organism...
Function ATP binding, catalytic activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (2)    Results (127)    Tissues (101)    Images (18)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 2   127
cDNA source data(8)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(12) cDNA(8) Primer pair(2) Other(2)
Microarray probesets(3)
Pathways
glycolysis III
glycolysis I
glycolysis II
Other database
links
EC 2.7.1.40
Ensembl Gene Model ENSMUSG00000041237
Consensus CDS Project CCDS17489.1
DFCI TC1586476
NIA Mouse Gene Index U003452
Entrez Gene 18770
VEGA Gene Model OTTMUSG00000017504
International Mouse Knockout Project Status Pklr
Protein
domains
InterPro ID Description
IPR001697 Pyruvate kinase
IPR011037 Pyruvate kinase, beta-barrel-like
IPR015793 Pyruvate kinase, barrel
IPR015794 Pyruvate kinase, alpha/beta
IPR015795 Pyruvate kinase, C-terminal-like
IPR015813 Pyruvate/Phosphoenolpyruvate kinase, catalytic core
IPR018209 Pyruvate kinase, active site
Graphical View of Protein Domain Structure
References
(Earliest) J:13777 Bulfield G et al., "[Pk-1]." Mouse News Lett 1978;59():29
(Latest) J:141722 Min-Oo G et al., "Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants." Blood Cells Mol Dis 2007 Jul-Aug;39(1):63-9
All references(39)
Other
accession IDs 		MGD-MRK-13318, MGD-MRK-13321, MGD-MRK-13337
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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