Symbol
Name
ID
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Synonyms
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Pkcz, zetaPKC
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(42)
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Alleles
and
phenotypes
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All alleles(11) :
Targeted, other(1)
Gene trapped(10)
| Young, not mature, homozygous null mice have reduced B cell numbers and abnormal secondary lymph organ structure. Young mice have fewer Peyer's patches, poor delineation of B & T cell zones, and fewer follicles of small size. Spleens have less prominent B cell follicles and abnormal marginal zones. |
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Polymorphisms
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SNPs within 2kb(504 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (25 records)
Data Summary:
Assays (9)
Results (301)
Tissues (222)
Images (67)
Theiler Stages: 3,4,5,11,13,15,17,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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Western blot |
2 |
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13 |
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RT-PCR |
3 |
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56 |
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RNA in situ |
2 |
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225 |
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Immunohistochemistry |
2 |
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7 |
cDNA source data(60)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(70)
Genomic(3)
cDNA(60)
Primer pair(7)
Antibodies(3)
Microarray probesets(5)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000270 |
Octicosapeptide/Phox/Bem1p |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000961 |
AGC-kinase, C-terminal |
| IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol binding |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR012233 |
Protein kinase C, zeta/iota |
| IPR015745 |
Protein kinase C |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
| IPR017892 |
Protein kinase, C-terminal |
| IPR020454 |
Diacylglycerol/phorbol-ester binding |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:10128
Wada H et al.,
"Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a."
Biochem Biophys Res Commun 1989 Nov 30;165(1):533-8
(Latest)
J:152174
Weimer JM et al.,
"MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex."
Development 2009 Sep;136(17):2965-75
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All references(65)
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Other
accession IDs
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MGD-MRK-13334, MGI:2140186, MGI:2140684, MGI:2140714
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