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Prkcd Gene Detail
 Symbol
Name
ID
Prkcd
protein kinase C, delta
MGI:97598

Nomenclature History
Synonyms D14Ertd420e, PKC[d], Pkcd, PKCdelta
Genetic Map
Chromosome 14
11.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr14:31408544-31439396 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Prkcd ± 2 cM)
Protein SuperFamily: protein kinase C, delta/epsilon/eta/theta types
TreeFam: TF102004
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000025129 VEGA Gene Model | MGI Sequence Detail 30853 C57BL/6J ± Kb
transcript NM_011103 RefSeq | MGI Sequence Detail 2536 C57BL/6
polypeptide P28867 UniProt | EBI | MGI Sequence Detail 674 Not Applicable
For the selected sequences
All sequences(52)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(1)
Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels.
Polymorphisms RFLP(3) SNPs within 2kb(149 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process B cell proliferation, immunoglobulin mediated immune response...
Component cytoplasm, membrane...
Function ATP binding, insulin receptor substrate binding...
External Resources: FuncBase
Expression Literature Summary: (16 records)
Data Summary: Assays (3)    Results (63)    Tissues (54)    Images (2)
Theiler Stages: 21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 2   17
      RT-PCR 1   46
cDNA source data(73)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(76) cDNA(74) Primer pair(2) Antibodies(2)
Microarray probesets(2)
Other database
links
EC 2.7.11.13
Ensembl Gene Model ENSMUSG00000021948
DoTS DT.101129641, DT.101400708, DT.101402781, DT.110745188, DT.110745213, DT.110745221, DT.492188, DT.97414946
Consensus CDS Project CCDS26895.1
UniGene 2314
PDB 1PTQ, 1PTR
DFCI TC1578909, TC1590684, TC1595933, TC1687695
NIA Mouse Gene Index U035358, U131879
Entrez Gene 18753
VEGA Gene Model OTTMUSG00000025129
International Mouse Knockout Project Status Prkcd
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR011009 Protein kinase-like domain
IPR014376 Protein kinase C, delta/epsilon/eta/theta types
IPR015745 Protein kinase C
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
Graphical View of Protein Domain Structure
References
(Earliest) J:2328 Mizuno K et al., "Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta." Eur J Biochem 1991 Dec 18;202(3):931-40
(Latest) J:154882 Pores-Fernando AT et al., "No specific subcellular localization of protein kinase C is required for cytotoxic T cell granule exocytosis." J Biol Chem 2009 Sep 11;284(37):25107-15
All references(101)
Other
accession IDs 		MGD-MRK-13330, MGI:1196301, MGI:2145627
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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