Symbol
Name
ID
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Synonyms
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D14Ertd420e, PKC[d], Pkcd, PKCdelta
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
|
All sequences(52)
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Alleles
and
phenotypes
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All alleles(4) :
Targeted, knock-out(2)
Targeted, other(1)
Gene trapped(1)
| Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels. |
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Polymorphisms
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RFLP(3)
SNPs within 2kb(149 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (16 records)
Data Summary:
Assays (3)
Results (63)
Tissues (54)
Images (2)
Theiler Stages: 21,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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46 |
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Western blot |
2 |
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17 |
cDNA source data(72)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(75)
cDNA(73)
Primer pair(2)
Antibodies(2)
Microarray probesets(2)
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Other database
links
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| EC |
2.7.11.13 |
| Ensembl Gene Model |
ENSMUSG00000021948 |
| DoTS |
DT.101129641, DT.101400708, DT.101402781, DT.110745188, DT.110745213, DT.110745221, DT.492188, DT.97414946 |
| UniGene |
2314 |
| PDB |
1PTQ, 1PTR |
| DFCI |
TC1578909, TC1590684, TC1595933, TC1687695 |
| NIA Mouse Gene Index |
U035358, U131879 |
| Entrez Gene |
18753 |
| VEGA Gene Model |
OTTMUSG00000025129 |
| International Mouse Knockout Project Status |
Prkcd |
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Protein
domains
|
| InterPro ID |
Description |
| IPR000008 |
C2 calcium-dependent membrane targeting |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000961 |
AGC-kinase, C-terminal |
| IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol binding |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR008973 |
C2 calcium/lipid-binding domain, CaLB |
| IPR011009 |
Protein kinase-like domain |
| IPR014376 |
Protein kinase C, delta/epsilon/eta/theta types |
| IPR015745 |
Protein kinase C |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
| IPR017892 |
Protein kinase, C-terminal |
| IPR020454 |
Diacylglycerol/phorbol-ester binding |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:2328
Mizuno K et al.,
"Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta."
Eur J Biochem 1991 Dec 18;202(3):931-40
(Latest)
J:153266
Chari R et al.,
"Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion."
Blood 2009 Oct 1;114(14):3056-63
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All references(95)
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Other
accession IDs
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MGD-MRK-13330, MGI:1196301, MGI:2145627
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