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Prkca Gene Detail
 Symbol
Name
ID
Prkca
protein kinase C, alpha
MGI:97595

Nomenclature History
Synonyms Pkca
Genetic Map
Chromosome 11
68.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 37)

Sequence Map
Chr11:107794701-108205242 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Prkca ± 2 cM)
Protein SuperFamily: protein kinase C, alpha/beta/gamma types
TreeFam: TF102004
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003131 VEGA Gene Model | MGI Sequence Detail 410542 C57BL/6J ± Kb
transcript NM_011101 RefSeq | MGI Sequence Detail 8385 C57BL/6
polypeptide P20444 UniProt | EBI | MGI Sequence Detail 672 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes 		All alleles(8) : Targeted, knock-out(3) Gene trapped(5)
Homozygous null mice show no overt macroscopic abnormalities, however examination of one line revealed increased cardiac muscle contractility and protection against heart failure.
Polymorphisms RFLP(5) SNPs within 2kb(1964 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular calcium ion homeostasis, chondrocyte differentiation...
Component cytoplasm, membrane...
Function ATP binding, calcium ion binding...
External Resources: FuncBase
Expression Literature Summary: (47 records)
Data Summary: Assays (7)    Results (221)    Tissues (160)    Images (18)
Theiler Stages: 21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 2   17
      RT-PCR 2   92
      RNA in situ 2   109
      Immunohistochemistry 1   3
cDNA source data(72)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(85) Genomic(3) cDNA(74) Primer pair(7) Other(1) Antibodies(3)
Microarray probesets(2)
Other database
links
EC 2.7.11.13
Ensembl Gene Model ENSMUSG00000050965
DoTS DT.110543235, DT.40185767, DT.97397898, DT.99854844
Consensus CDS Project CCDS25573.1
UniGene 222178
DFCI TC1581794, TC1591923, TC1597961
NIA Mouse Gene Index U033564, U228381
Entrez Gene 18750
VEGA Gene Model OTTMUSG00000003131
International Mouse Knockout Project Status Prkca
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR011009 Protein kinase-like domain
IPR014375 Protein kinase C, alpha/beta/gamma types
IPR015745 Protein kinase C
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR018029 C2 membrane targeting protein
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020477 C2 region
Graphical View of Protein Domain Structure
References
(Earliest) J:12309 Yang-Feng TL et al., "Protein kinase C genes in the mouse: Pkca maps to MMU 11 and Pkcc to MMU7." Cytogenet Cell Genet 1987;46():723
(Latest) J:152506 Jin ZB et al., "Targeted deletion of miR-182, an abundant retinal microRNA." Mol Vis 2009;15():523-33
All references(145)
Other
accession IDs 		MGD-MRK-13327, MGI:2144325
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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