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Prkacb Gene Detail
 Symbol
Name
ID
Prkacb
protein kinase, cAMP dependent, catalytic, beta
MGI:97594

Nomenclature History
Synonyms cAMP-dependent protein kinase C beta, Pkacb
Genetic Map
Chromosome 3
cytoband H3
 
Mapping data( 3)
Sequence Map
Chr3:146392543-146475924 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF313399
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016475 VEGA Gene Model | MGI Sequence Detail 83382 C57BL/6J ± Kb
transcript NM_011100 RefSeq | MGI Sequence Detail 4341 C57BL/6
polypeptide P68181 UniProt | EBI | MGI Sequence Detail 351 Not Applicable
For the selected sequences
All sequences(48)
Alleles
and
phenotypes 		All alleles(16) : Targeted, knock-out(2) Gene trapped(14)
Homozygotes for a targeted null mutation eliminating the Cbeta1 subunit exhibit impaired hippocampal plasticity, including failure of low frequency stimulation to produce lasting depression and the elimination of mossy fiber long term potentiation.
Phenotype Images (2)  
Polymorphisms SNPs within 2kb(471 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process G-protein signaling, coupled to cAMP nucleotide second messenger, protein amino acid phosphorylation...
Component cAMP-dependent protein kinase complex, cytoplasm...
Function ATP binding, cAMP-dependent protein kinase activity...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (143)    Tissues (139)    Images (18)
Theiler Stages: 22,23,26,28
  Assay Type Assays   Results
      RT-PCR 2   50
      RNA in situ 1   93
cDNA source data(202)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(210) Genomic(4) cDNA(203) Primer pair(3)
Microarray probesets(3)
Other database
links
EC 2.7.11.11
Ensembl Gene Model ENSMUSG00000005034
DoTS DT.101276761, DT.103567270, DT.111048569, DT.536371, DT.91360853, DT.91406819
Consensus CDS Project CCDS17906.1
UniGene 16766
DFCI TC1579950, TC1614194, TC1638534, TC1641717
NIA Mouse Gene Index U024745
Entrez Gene 18749
VEGA Gene Model OTTMUSG00000016475
International Mouse Knockout Project Status Prkacb
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:35384 Uhler MD et al., "Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase [published erratum appears in J Biol Chem 1987 Apr 15;262(11):5431]" J Biol Chem 1986 Nov 25;261(33):15360-3
(Latest) J:140076 Oksvold MP et al., "Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit." BMC Cell Biol 2008;9():16
All references(28)
Other
accession IDs 		MGD-MRK-13325
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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