Symbol
Name
ID
|
|
|
Synonyms
|
C alpha, Cs, PKA, Pkaca
|
|
Genetic Map
|
|
Chromosome 8
|
cytoband C3
|
|
|
|
Mapping data(
1)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(35)
|
Alleles
and
phenotypes
|
All alleles(3) :
Targeted, knock-out(2)
Targeted, other(1)
| Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility. |
|
|
Polymorphisms
|
SNPs within 2kb(65 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (9 records)
Data Summary:
Assays (4)
Results (147)
Tissues (143)
Images (18)
Theiler Stages: 20,21,22,23,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
50 |
| |
RNA in situ |
1 |
|
94 |
| |
Northern blot |
1 |
|
3 |
cDNA source data(120)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(126)
Genomic(3)
cDNA(120)
Primer pair(3)
Microarray probesets(2)
|
Other database
links
|
| EC |
2.7.11.11 |
| Ensembl Gene Model |
ENSMUSG00000005469 |
| DoTS |
DT.110851851, DT.535374, DT.91341731, DT.94263558 |
| UniGene |
19111 |
| PDB |
1APM, 1ATP, 1BKX, 1BX6, 1FMO, 1J3H, 1JBP, 1JLU, 1L3R, 1PVK, 1RDQ, 1RE8, 1REJ, 1REK, 1SYK, 2CPK, 2ERZ, 2QCS, 2QUR, 2QVS, 3FHI, 3FJQ |
| DFCI |
TC1586161, TC1656824, TC1712115, TC1777159 |
| NIA Mouse Gene Index |
U009562 |
| Entrez Gene |
18747 |
| International Mouse Knockout Project Status |
Prkaca |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000961 |
AGC-kinase, C-terminal |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:25675
Uhler MD et al.,
"Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase."
Proc Natl Acad Sci U S A 1986 Mar;83(5):1300-4
(Latest)
J:154195
Yamamizu K et al.,
"Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1."
Blood 2009 Oct 22;114(17):3707-16
|
All references(61)
|
Other
accession IDs
|
MGD-MRK-13323
|
|
