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Prkaca Gene Detail
 Symbol
Name
ID
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
MGI:97592

Nomenclature History
Synonyms C alpha, Cs, PKA, Pkaca
Genetic Map
Chromosome 8
cytoband C3
 
Mapping data( 1)
Sequence Map
Chr8:86496887-86520334 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000005469 Ensembl Gene Model | MGI Sequence Detail 23448 C57BL/6J ± Kb
transcript NM_008854 RefSeq | MGI Sequence Detail 2293 -
polypeptide P05132 UniProt | EBI | MGI Sequence Detail 351 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(2) Targeted, other(1)
Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility.
Phenotype Images (2)  
Polymorphisms SNPs within 2kb(65 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process mesoderm formation, positive regulation of protein export from nucleus...
Component cytoplasm, cytosol...
Function ATP binding, cAMP-dependent protein kinase activity...
External Resources: FuncBase
Expression Literature Summary: (9 records)
Data Summary: Assays (4)    Results (147)    Tissues (143)    Images (18)
Theiler Stages: 20,21,22,23,26,28
  Assay Type Assays   Results
      RT-PCR 2   50
      RNA in situ 1   94
      Northern blot 1   3
cDNA source data(120)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(126) Genomic(3) cDNA(120) Primer pair(3)
Microarray probesets(2)
Other database
links
EC 2.7.11.11
Ensembl Gene Model ENSMUSG00000005469
DoTS DT.110851851, DT.535374, DT.91341731, DT.94263558
Consensus CDS Project CCDS22463.1
UniGene 19111
PDB 1APM, 1ATP, 1BKX, 1BX6, 1FMO, 1J3H, 1JBP, 1JLU, 1L3R, 1PVK, 1RDQ, 1RE8, 1REJ, 1REK, 1SYK, 2CPK, 2ERZ, 2QCS, 2QUR, 2QVS, 3FHI, 3FJQ, 3IDB, 3IDC
DFCI TC1586161, TC1656824, TC1712115, TC1777159
NIA Mouse Gene Index U009562
Entrez Gene 18747
International Mouse Knockout Project Status Prkaca
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:25675 Uhler MD et al., "Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase." Proc Natl Acad Sci U S A 1986 Mar;83(5):1300-4
(Latest) J:154195 Yamamizu K et al., "Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1." Blood 2009 Oct 22;114(17):3707-16
All references(61)
Other
accession IDs 		MGD-MRK-13323
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory