Symbol
Name
ID
|
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
MGI:97583
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Nomenclature History
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Synonyms
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p50alpha, p55alpha, p85alpha, PI3K
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(46)
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Alleles
and
phenotypes
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All alleles(18) :
Targeted, knock-out(3)
Targeted, other(1)
Gene trapped(14)
| Homozygotes for a targeted null mutation exhibit perinatal lethality associated with hepatic necrosis, chylous ascites, enlarged muscle fibers, calcification of cardiac tissue, and hypoglycemia. Mutants lacking only the major isoform are immunodeficient. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (2)
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Polymorphisms
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All PCR and RFLP(2) :
PCR(1)
RFLP(1)
SNPs within 2kb(336 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (13 records)
Data Summary:
Assays (3)
Results (46)
Tissues (31)
Images (1)
Theiler Stages: 21,22,23,24,25,26,28
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Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
9 |
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RNA in situ |
1 |
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12 |
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Northern blot |
1 |
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25 |
cDNA source data(104)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(116)
Genomic(9)
cDNA(106)
Primer pair(1)
Antibodies(1)
Microarray probesets(4)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000041417 |
| DoTS |
DT.101164583, DT.101356000, DT.110975228, DT.487883, DT.87034068 |
| Consensus CDS Project |
CCDS26740.1, CCDS36769.1 |
| UniGene |
259333 |
| DFCI |
TC1581848, TC1582013, TC1642133, TC1666508, TC1692216, TC1731222 |
| NIA Mouse Gene Index |
U035123 |
| Entrez Gene |
18708 |
| International Mouse Knockout Project Status |
Pik3r1 |
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Protein
domains
|
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:17845
Escobedo JA et al.,
"cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor."
Cell 1991 Apr 5;65(1):75-82
(Latest)
J:152818
Melnick M et al.,
"Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm."
BMC Dev Biol 2009;9():32
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All references(119)
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Other
accession IDs
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MGD-MRK-13305, MGI:2145159
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Analysis Tools
MGI BioMart
