Symbol
Name
ID
|
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
MGI:97583
|
Nomenclature History
|
|
|
Synonyms
|
p50alpha, p55alpha, p85alpha, PI3K
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(46)
|
Alleles
and
phenotypes
|
All alleles(17) :
Targeted, knock-out(3)
Targeted, other(1)
Gene trapped(13)
| Homozygotes for a targeted null mutation exhibit perinatal lethality associated with hepatic necrosis, chylous ascites, enlarged muscle fibers, calcification of cardiac tissue, and hypoglycemia. Mutants lacking only the major isoform are immunodeficient. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (2)
|
|
Polymorphisms
|
All PCR and RFLP(2) :
PCR(1)
RFLP(1)
SNPs within 2kb(336 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (3)
Results (46)
Tissues (31)
Images (1)
Theiler Stages: 21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
9 |
| |
RNA in situ |
1 |
|
12 |
| |
Northern blot |
1 |
|
25 |
cDNA source data(104)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(116)
Genomic(9)
cDNA(106)
Primer pair(1)
Antibodies(1)
Microarray probesets(4)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:17845
Escobedo JA et al.,
"cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor."
Cell 1991 Apr 5;65(1):75-82
(Latest)
J:152818
Melnick M et al.,
"Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm."
BMC Dev Biol 2009;9():32
|
All references(116)
|
Other
accession IDs
|
MGD-MRK-13305, MGI:2145159
|
