Symbol
Name
ID
|
|
|
Synonyms
|
CD140a, Pdgfr-2
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(49)
|
Alleles
and
phenotypes
|
All alleles(15) :
Targeted, knock-out(2)
Targeted, other(13)
| Homozygotes for targeted null mutations exhibit incomplete cephalic closure, increased apoptosis of neural crest cells, impaired myotome and testis formation, abnormal mucosal linings, thoracic skeletal defects, and midgestational lethality. |
|
|
Polymorphisms
|
RFLP(10)
SNPs within 2kb(210 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (166 records)
Data Summary:
Assays (30)
Results (425)
Tissues (288)
Images (104)
Theiler Stages: 9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
8 |
| |
RT-PCR |
2 |
|
46 |
| |
RNA in situ |
22 |
|
345 |
| |
Immunohistochemistry |
1 |
|
2 |
| |
Northern blot |
2 |
|
8 |
| |
RNase protection |
2 |
|
16 |
cDNA source data(39)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(79)
Genomic(9)
cDNA(52)
Primer pair(3)
Other(15)
Antibodies(2)
Microarray probesets(3)
|
Other database
links
|
| EC |
2.7.10.1 |
| Ensembl Gene Model |
ENSMUSG00000029231 |
| DoTS |
DT.101174656, DT.101386045, DT.101386048, DT.101738466, DT.110651179, DT.40155758, DT.534547 |
| DFCI |
TC1577498, TC1586618, TC1594036, TC1624852, TC1633686, TC1695594, TC1713840 |
| NIA Mouse Gene Index |
U040640 |
| Entrez Gene |
18595 |
| International Mouse Knockout Project Status |
Pdgfra |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR001245 |
Tyrosine-protein kinase, catalytic domain |
| IPR001824 |
Tyrosine-protein kinase, receptor class III, conserved site |
| IPR003598 |
Immunoglobulin subtype 2 |
| IPR003599 |
Immunoglobulin subtype |
| IPR007110 |
Immunoglobulin-like |
| IPR008266 |
Tyrosine-protein kinase, active site |
| IPR009134 |
Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal |
| IPR013098 |
Immunoglobulin I-set |
| IPR013151 |
Immunoglobulin |
| IPR013783 |
Immunoglobulin-like fold |
| IPR015776 |
Tyrosine-protein kinase, platelet-derived growth factor receptor alpha |
| IPR016243 |
Tyrosine-protein kinase, CSF-1/PDGF receptor |
| IPR017441 |
Protein kinase, ATP binding site |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:99
Gruneberg H et al.,
"Two closely linked genes in the mouse"
Genet Res 1960;1():69-90
(Latest)
J:154167
Morikawa S et al.,
"Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow."
J Exp Med 2009 Oct 26;206(11):2483-96
|
All references(236)
|
Other
accession IDs
|
MGD-MRK-13215, MGD-MRK-13216, MGI:2140805
|
|
