About   Help   FAQ
Nras Gene Detail
 Symbol
Name
ID
Nras
neuroblastoma ras oncogene
MGI:97376


Nomenclature History
Synonyms N-ras
Genetic Map
Chromosome 3
48.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 19)

Sequence Map
Chr3:102862262-102871837 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Nras ± 2 cM)
Protein SuperFamily: ras protein
TreeFam: TF312796
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021269 VEGA Gene Model | MGI Sequence Detail 9576 C57BL/6J ± Kb
transcript NM_010937 RefSeq | MGI Sequence Detail 4470 -
polypeptide P08556 UniProt | EBI | MGI Sequence Detail 189 Not Applicable
For the selected sequences
All sequences(39)
Alleles
and
phenotypes
All alleles(30) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(27)
Mice homozygous for a targeted mutation are viable and fertile with no gross morphological or histological abnormalities, or defects in peripheral blood cell populations.
Polymorphisms RFLP(5) SNPs within 2kb(31 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process Ras protein signal transduction, regulation of cell cycle...
Component Golgi apparatus, intracellular...
Function GTP binding, GTPase activity...
External Resources: FuncBase
Expression Literature Summary: (8 records)
Data Summary: Assays (4)    Results (15)    Tissues (3)    Images (3)
Theiler Stages: 22,24
  Assay Type Assays   Results
      Western blot 3   13
      RNA in situ 1   2
cDNA source data(169)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(187) Genomic(13) cDNA(171) Other(3) Antibodies(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000027852
DoTS DT.101384061, DT.529712, DT.94339287
Consensus CDS Project CCDS38570.1
UniGene 400954
DFCI TC1574136, TC1763053
NIA Mouse Gene Index U003655
Entrez Gene 18176
VEGA Gene Model OTTMUSG00000021269
International Mouse Knockout Project Status Nras
Protein
domains
InterPro ID Description
IPR001806 Ras GTPase
IPR003577 Ras small GTPase, Ras type
IPR005225 Small GTP-binding protein
IPR013753 Ras
IPR015592 Ras small GTPase, Ras-related
IPR020849 Ras small GTPase
Graphical View of Protein Domain Structure
References
(Earliest) J:7034 Shimizu K et al., "Three human transforming genes are related to the viral ras oncogenes." Proc Natl Acad Sci U S A 1983 Apr;80(8):2112-6
(Latest) J:145761 Casar B et al., "Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins." Mol Cell Biol 2009 Mar;29(5):1338-53
All references(62)
Other
accession IDs
MGD-MRK-12932, MGI:2139934

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory