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Nek1 Gene Detail
 Symbol
Name
ID
Nek1
NIMA (never in mitosis gene a)-related expressed kinase 1
MGI:97303


Nomenclature History
Synonyms D8Ertd790e, kat, kidney, anemia and testis
Genetic Map
Chromosome 8
32.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr8:63471992-63610143 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Nek1 ± 2 cM)
TreeFam: TF106472
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000031430 VEGA Gene Model | MGI Sequence Detail 138152 C57BL/6J ± Kb
transcript NM_175089 RefSeq | MGI Sequence Detail 4264 -
polypeptide P51954 UniProt | EBI | MGI Sequence Detail 1203 Not Applicable
For the selected sequences
All sequences(42)
Alleles
and
phenotypes
All alleles(3) : Gene trapped(1) Spontaneous(2)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (2)  
Polymorphisms RFLP(1) SNPs within 2kb(352 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(19)
Process cell cycle, cell division...
Component cytoplasm, nucleus...
Function ATP binding, kinase activity...
External Resources: MouseFunc
Expression Literature Summary: (3 records)
Data Summary: Assays (3)    Results (11)    Tissues (7)
Theiler Stages: 20,28
  Assay Type Assays   Results
      Western blot 3   11
cDNA source data(24)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1) Antibodies(1)
Microarray probesets(1)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000031644
DoTS DT.101735484, DT.55146382, DT.87032680, DT.94130738, DT.94189081, DT.97412204
DFCI TC1582305, TC1593842, TC1595987, TC1597589, TC1620215
NIA Mouse Gene Index U009368
Entrez Gene 18004
VEGA Gene Model OTTMUSG00000031430
International Mouse Knockout Project Status Nek1
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:2376 Letwin K et al., "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells." EMBO J 1992 Oct;11(10):3521-31
(Latest) J:134248 Shalom O et al., "The mammalian Nek1 kinase is involved in primary cilium formation." FEBS Lett 2008 Apr 30;582(10):1465-70
All references(19)
Other
accession IDs
MGD-MRK-12816, MGD-MRK-38304, MGI:109259, MGI:1289217

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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