About   Help   FAQ
Tour our new Quick Search
Myc Gene Detail
 Symbol
Name
ID
Myc
myelocytomatosis oncogene
MGI:97250

Nomenclature History
STS D15Mit17,D15Nds3
Synonyms bHLHe39, c-myc, Myc2, Niard, Nird
Genetic Map
Chromosome 15
32.0 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM
 
Mapping data( 63)

Sequence Map
Chr15:61816946-61821929 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Myc ± 2 cM)
Protein SuperFamily: myc protein, c-myc/v-myc types
TreeFam: TF106001
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000034892 VEGA Gene Model | MGI Sequence Detail 4984 C57BL/6J ± Kb
transcript NM_010849 RefSeq | MGI Sequence Detail 2399 C57BL/6
polypeptide P01108 UniProt | EBI | MGI Sequence Detail 439 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes 		All alleles(19) : Targeted, knock-out(7) Targeted, other(10) Gene trapped(2)
Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (1)  
Polymorphisms All PCR and RFLP(19) : PCR(5) RFLP(14) SNPs within 2kb(7 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process activation of caspase activity, activation of pro-apoptotic gene products...
Component axon, nuclear body...
Function DNA binding, protein binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (94 records)
Data Summary: Assays (15)    Results (147)    Tissues (83)    Images (12)
Theiler Stages: 1,2,3,4,5,14,15,17,18,19,20,21,22,23,24,25,28
  Assay Type Assays   Results
      Western blot 1   2
      RT-PCR 5   51
      RNA in situ 6   45
      Northern blot 2   47
      RNase protection 1   2
cDNA source data(74)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(144) Genomic(46) cDNA(74) Primer pair(7) Other(17) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022346
DoTS DT.101347643, DT.94304896
Consensus CDS Project CCDS27504.1
UniGene 2444
DFCI TC1574039
NIA Mouse Gene Index U016291
Entrez Gene 17869
VEGA Gene Model OTTMUSG00000034892
International Mouse Knockout Project Status Myc
Protein
domains
InterPro ID Description
IPR001092 Helix-loop-helix DNA-binding domain
IPR002418 Transcription regulator Myc
IPR003327 Leucine zipper, Myc
IPR011598 Helix-loop-helix DNA-binding
IPR012682 Transcription regulator Myc, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:6848 Harris LJ et al., "Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas." Proc Natl Acad Sci U S A 1982 Jul;79(13):4175-9
(Latest) J:154623 Kim WY et al., "GSK-3 is a master regulator of neural progenitor homeostasis." Nat Neurosci 2009 Nov;12(11):1390-7
All references(393)
Other
accession IDs 		MGD-MRK-12736, MGI:2146128
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory