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Mdh1 Gene Detail
 Symbol
Name
ID
Mdh1
malate dehydrogenase 1, NAD (soluble)
MGI:97051

Nomenclature History
Synonyms B230377B03Rik, MDH-s, Mor-2, Mor2
Genetic Map
Chromosome 11
12.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 10)

Sequence Map
Chr11:21456790-21472370 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; lemur, mouse; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Mdh1 ± 2 cM)
Protein SuperFamily: L-lactate/malate dehydrogenase
TreeFam: TF105826
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005249 VEGA Gene Model | MGI Sequence Detail 15581 C57BL/6J ± Kb
transcript NM_008618 RefSeq | MGI Sequence Detail 1958 C57BL/6
polypeptide P14152 UniProt | EBI | MGI Sequence Detail 334 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes 		All alleles(4) : Gene trapped(3) Chemically induced(1)
Polymorphisms PCR(1) SNPs within 2kb(57 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(19)
Process carbohydrate metabolic process, cellular carbohydrate metabolic process...
Component cytoplasm, cytosol...
Function binding, catalytic activity...
External Resources: MouseFunc
Expression Literature Summary: (2 records)
Data Summary: Assays (3)    Results (189)    Tissues (96)    Images (38)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 3   189
cDNA source data(18)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(27) Genomic(5) cDNA(20) Primer pair(2)
Microarray probesets(2)
Pathways
gluconeogenesis
incomplete reductive TCA cycle
TCA cycle variation III (eukaryotic)
TCA cycle
Other database
links
EC 1.1.1.37
Ensembl Gene Model ENSMUSG00000020321
DoTS DT.101402611, DT.55166722, DT.94411845, DT.97332493
DFCI TC1573767, TC1598349
NIA Mouse Gene Index U032561
Entrez Gene 17449
VEGA Gene Model OTTMUSG00000005249
International Mouse Knockout Project Status Mdh1
Protein
domains
InterPro ID Description
IPR001236 Lactate/malate dehydrogenase
IPR001252 Malate dehydrogenase, active site
IPR001557 L-lactate/malate dehydrogenase
IPR010945 Malate dehydrogenase, NAD/NADP
IPR011274 Malate dehydrogenase, NAD-dependent, cytosolic
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR016040 NAD(P)-binding domain
Graphical View of Protein Domain Structure
References
(Earliest) J:5187 Shows TB et al., "Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse." Biochem Genet 1970 Dec;4(6):707-18
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(15)
Other
accession IDs 		MGD-MRK-12354, MGD-MRK-12356, MGI:1337125, MGI:2443968
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory