Symbol
Name
ID
|
|
|
Synonyms
|
ALL-1, All1, Cxxc7, HTRX1, KMT2A, Mll, trithorax Drosophila
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(31)
|
Alleles
and
phenotypes
|
All alleles(23) :
Targeted, knock-out(4)
Targeted, other(11)
Gene trapped(8)
| Homozygotes for targeted null mutations die at embryonic day 11.5-14.5 with edematous bodies, petechiae, and hematopoietic insufficiency. Heterozygotes show reduced growth, hematopoietic abnormalities, and homeotic transformations of the axial skeleton. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (2)
Phenotype Images (2)
|
|
Polymorphisms
|
RFLP(1)
SNPs within 2kb(496 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (7 records)
Data Summary:
Assays (3)
Results (42)
Tissues (38)
Images (7)
Theiler Stages: 17,21,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RNA in situ |
3 |
|
42 |
cDNA source data(151)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(159)
Genomic(4)
cDNA(153)
Primer pair(2)
Microarray probesets(3)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR001214 |
SET domain |
| IPR001487 |
Bromodomain |
| IPR001965 |
Zinc finger, PHD-type |
| IPR002857 |
Zinc finger, CXXC-type |
| IPR003616 |
Post-SET domain |
| IPR003888 |
FY-rich, N-terminal |
| IPR003889 |
FY-rich, C-terminal |
| IPR011011 |
Zinc finger, FYVE/PHD-type |
| IPR015722 |
MLL Transcription Factor |
| IPR016569 |
Methyltransferase, trithorax |
| IPR017956 |
AT hook, DNA-binding motif |
| IPR018516 |
FY-rich, C-terminal subgroup |
| IPR018518 |
FY-rich, N-terminal subgroup |
| IPR019786 |
Zinc finger, PHD-type, conserved site |
| IPR019787 |
Zinc finger, PHD-finger |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:34109
Tkachuk DC et al.,
"Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias."
Cell 1992 Nov 13;71(4):691-700
(Latest)
J:154938
Wang P et al.,
"Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II."
Mol Cell Biol 2009 Nov;29(22):6074-85
|
All references(53)
|
Other
accession IDs
|
MGD-MRK-12254, MGD-MRK-1281
|
Analysis Tools
MGI BioMart
