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Alad Gene Detail
 Symbol
Name
ID
Alad
aminolevulinate, delta-, dehydratase
MGI:96853


Nomenclature History
Synonyms Lv
Genetic Map
Chromosome 4
30.6 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 18)

Sequence Map
Chr4:62170203-62180952 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Alad ± 2 cM)
Protein SuperFamily: porphobilinogen synthase
TreeFam: TF300665
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009022 VEGA Gene Model | MGI Sequence Detail 10750 C57BL/6J ± Kb
transcript NM_008525 RefSeq | MGI Sequence Detail 1392 FVB/N
polypeptide P10518 UniProt | EBI | MGI Sequence Detail 330 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes
All alleles(10) : Gene trapped(10)
Polymorphisms RFLP(10) SNPs within 2kb(64 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(11)
Process heme biosynthetic process, metabolic process...
Function catalytic activity, identical protein binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (4 records)
Data Summary: Assays (5)    Results (14)    Tissues (7)
Theiler Stages: 15,22,28
  Assay Type Assays   Results
      Nuclease S1 2   6
      RNase protection 3   8
cDNA source data(11)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(31) Genomic(14) cDNA(17)
Microarray probesets(2)
Pathways
tetrapyrrole biosynthesis II
heme biosynthesis II
Other database
links
EC 4.2.1.24
Ensembl Gene Model ENSMUSG00000028393
DoTS DT.531948, DT.536177, DT.94215635, DT.99861814
PDB 2Z0I, 2Z1B
DFCI TC1574739, TC1586559, TC1635794
NIA Mouse Gene Index U025144
Entrez Gene 17025
VEGA Gene Model OTTMUSG00000009022
International Mouse Knockout Project Status Alad
Protein
domains
InterPro ID Description
IPR001731 Tetrapyrrole biosynthesis, porphobilinogen synthase
IPR013785 Aldolase-type TIM barrel
Graphical View of Protein Domain Structure
References
(Earliest) J:14972 Russell RL et al., "Genetic control of hepatic delta-aminolevulinate dehydratase in mice" Genetics 1963 Aug;48():1033-39
(Latest) J:123174 Robert-Moreno A et al., "The notch pathway positively regulates programmed cell death during erythroid differentiation." Leukemia 2007 Jul;21(7):1496-503
All references(35)
Other
accession IDs
MGD-MRK-11931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory