Symbol
Name
ID
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(51)
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Alleles
and
phenotypes
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All alleles(29) :
Targeted, knock-out(1)
Targeted, other(3)
Gene trapped(23)
Chemically induced(2)
| Homozygous targeted mutants exhibit 2X higher total plasma cholesterol and 7-9X higher IDL and LDL levels on a normal diet compared to controls. On a high cholesterol diet, mutant effects dramatically increase and mice develop xanthomatosis and atherosclerosis. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (2)
Phenotype Images (7)
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Polymorphisms
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RFLP(8)
SNPs within 2kb(92 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (12 records)
Data Summary:
Assays (11)
Results (55)
Tissues (21)
Images (9)
Theiler Stages: 1,2,3,4,5,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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17 |
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Northern blot |
10 |
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38 |
cDNA source data(118)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(133)
Genomic(6)
cDNA(124)
Primer pair(2)
Other(1)
Microarray probesets(4)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000032193 |
| DoTS |
DT.101162065, DT.101209477, DT.101228881, DT.101235629, DT.101280743, DT.101400484, DT.531817, DT.55195832 |
| UniGene |
3213 |
| DFCI |
TC1572220, TC1596072, TC1596367, TC1621863, TC1650174, TC1666618, TC1738660 |
| NIA Mouse Gene Index |
U010151 |
| Entrez Gene |
16835 |
| International Mouse Knockout Project Status |
Ldlr |
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Protein
domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:30079
Brown MS et al.,
"A receptor-mediated pathway for cholesterol homeostasis."
Science 1986 Apr 4;232(4746):34-47
(Latest)
J:153626
Zhou L et al.,
"LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation."
PLoS One 2009;4(9):e6922
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All references(517)
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Other
accession IDs
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MGD-MRK-11774, MGI:2683059
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