Symbol
Name
ID
|
Kcne1
potassium voltage-gated channel, Isk-related subfamily, member 1
MGI:96673
|
Nomenclature History
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Synonyms
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Isk, MinK, nmf190
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(14)
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Alleles
and
phenotypes
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All alleles(4) :
Targeted, knock-out(1)
Targeted, other(1)
Spontaneous(1)
Chemically induced(1)
| Homozygotes for targeted and spontaneous null mutations exhibit head-shaking, circling, ataxia, and severe deafness associated with inner ear defects. Older mutants show increased numbers of T cells. Study of cardiac myocytes in one line showed physiologic defects. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (2)
Phenotype Images (2)
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Polymorphisms
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SNPs within 2kb(109 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (14)
Results (84)
Tissues (37)
Images (2)
Theiler Stages: 13,15,17,20,23,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
5 |
|
30 |
| |
RNA in situ |
4 |
|
24 |
| |
Northern blot |
5 |
|
30 |
cDNA source data(18)
External Resources:
GEO
|
Molecular
reagents
|
All nucleic(24)
Genomic(1)
cDNA(19)
Primer pair(4)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR000369 |
Potassium channel, voltage-dependent, beta subunit, KCNE |
| IPR005424 |
Potassium channel, voltage-dependent, beta subunit, KCNE1 |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:11462
Honore E et al.,
"Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart."
EMBO J 1991 Oct;10(10):2805-11
(Latest)
J:150452
Zhou B et al.,
"Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart."
J Clin Invest 2009 Jun;119(6):1462-76
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All references(44)
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Other
accession IDs
|
MGD-MRK-11577, MGI:2678336
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