Symbol
Name
ID
|
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Synonyms
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D930025P04Rik, gamma-catenin, PG, plakoglobin
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(25)
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Alleles
and
phenotypes
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All alleles(139) :
Targeted, knock-out(2)
Gene trapped(137)
| Homozygous null mutants die with severe heart defects at embryonic day 10.5-16, depending on genetic background. Mutants that survive to birth exhibit skin blistering and subcorneal acantholysis associated with reduced number of desmosomes. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (2)
Phenotype Images (3)
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Polymorphisms
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RFLP(2)
SNPs within 2kb(80 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (28 records)
Data Summary:
Assays (5)
Results (66)
Tissues (58)
Images (3)
Theiler Stages: 20,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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Western blot |
1 |
|
1 |
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RT-PCR |
1 |
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46 |
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Immunohistochemistry |
3 |
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19 |
cDNA source data(276)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(280)
cDNA(279)
Primer pair(1)
Antibodies(5)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:37381
Cowin P et al.,
"Plakoglobin: a protein common to different kinds of intercellular adhering junctions."
Cell 1986 Sep 26;46(7):1063-73
(Latest)
J:148138
Acehan D et al.,
"Plakoglobin is required for effective intermediate filament anchorage to desmosomes."
J Invest Dermatol 2008 Nov;128(11):2665-75
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All references(59)
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Other
accession IDs
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MGD-MRK-11544, MGI:2144342, MGI:2144558
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