Symbol
Name
ID
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Synonyms
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c-jun, Junc
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(35)
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Alleles
and
phenotypes
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All alleles(10) :
Targeted, knock-out(2)
Targeted, other(8)
| Null homozygotes die at midgestation with impaired hepatogenesis, altered fetal liver erythropoiesis and edema. A mutant replacing two serines by alanines is viable, fertile, small-sized and resistant to kainate-induced seizures and neuronal apoptosis. |
Phenotype Images (4)
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Polymorphisms
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All PCR and RFLP(9) :
PCR(1)
RFLP(8)
SNPs within 2kb(26 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
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Literature Summary: (57 records)
Data Summary:
Assays (9)
Results (292)
Tissues (182)
Images (41)
Theiler Stages: 2,3,4,5,11,12,13,14,16,18,19,20,21,22,23,28
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Assay Type |
Assays |
|
Results |
| |
RT-PCR |
5 |
|
160 |
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RNA in situ |
3 |
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128 |
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Northern blot |
1 |
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4 |
cDNA source data(129)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(146)
Genomic(5)
cDNA(134)
Primer pair(5)
Other(2)
Microarray probesets(3)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR002112 |
Transcription factor Jun |
| IPR004827 |
Basic-leucine zipper (bZIP) transcription factor |
| IPR005643 |
Jun-like transcription factor |
| IPR008917 |
Eukaryotic transcription factor, Skn-1-like, DNA-binding |
| IPR011616 |
bZIP transcription factor, bZIP-1 |
| IPR015558 |
c-Jun Transcription Factor |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:9056
Ryder K et al.,
"A gene activated by growth factors is related to the oncogene v-jun."
Proc Natl Acad Sci U S A 1988 Mar;85(5):1487-91
(Latest)
J:152902
Nalapareddy P et al.,
"The BH3-only protein bid does not mediate death-receptor-induced liver injury in obstructive cholestasis."
Am J Pathol 2009 Sep;175(3):1077-85
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All references(206)
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Other
accession IDs
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MGD-MRK-11538, MGD-MRK-11540
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