Symbol
Name
ID
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Synonyms
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4932439J01Rik, CD220, D630014A15Rik, IR
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(34)
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Alleles
and
phenotypes
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All alleles(9) :
Targeted, knock-out(2)
Targeted, other(2)
Gene trapped(2)
Chemically induced(3)
| Null mutants grow slowly and die by 7 days of age with ketoacidosis, high serum insulin and triglycerides, low glycogen stores and fatty livers. Tissue specific knockouts show milder lipid metabolism anomalies. Point mutation heterozygotes exhibit hyperglycemia, hyperinsulinemia and glucosuria. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(472 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (13 records)
Data Summary:
Assays (3)
Results (13)
Tissues (10)
Images (2)
Theiler Stages: 2,3,5,11,13,15,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
3 |
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13 |
cDNA source data(73)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(83)
Genomic(5)
cDNA(74)
Primer pair(2)
Other(2)
Microarray probesets(4)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000494 |
EGF receptor, L domain |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR001245 |
Tyrosine-protein kinase, catalytic domain |
| IPR002011 |
Tyrosine-protein kinase, receptor class II, conserved site |
| IPR003961 |
Fibronectin, type III |
| IPR006211 |
Furin-like cysteine-rich domain |
| IPR006212 |
Furin-like repeat |
| IPR008266 |
Tyrosine-protein kinase, active site |
| IPR008957 |
Fibronectin, type III-like fold |
| IPR009030 |
Growth factor, receptor |
| IPR011009 |
Protein kinase-like domain |
| IPR016246 |
Tyrosine-protein kinase, insulin-like receptor |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR020635 |
Tyrosine-protein kinase, subgroup, catalytic domain |
| IPR020685 |
Tyrosine-protein kinase |
| IPR020710 |
Tyrosine-protein kinase, insulin receptor |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:9626
Wang LM et al.,
"Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors."
Genomics 1988 Aug;3(2):172-6
(Latest)
J:155641
Esquiliano DR et al.,
"Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations."
Placenta 2009 Aug;30(8):693-9
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All references(154)
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Other
accession IDs
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MGD-MRK-11417, MGI:2442502, MGI:2443766
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Analysis Tools
MGI BioMart
