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Insr Gene Detail
 Symbol
Name
ID
Insr
insulin receptor
MGI:96575


Nomenclature History
Synonyms 4932439J01Rik, CD220, D630014A15Rik, IR
Genetic Map
Chromosome 8
1.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 11)

Sequence Map
Chr8:3150922-3279617 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Insr ± 2 cM)
Protein SuperFamily: insulin receptor
TreeFam: TF351636
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000031438 VEGA Gene Model | MGI Sequence Detail 128696 C57BL/6J ± Kb
transcript NM_010568 RefSeq | MGI Sequence Detail 9357 C57BL/6
polypeptide P15208 UniProt | EBI | MGI Sequence Detail 1372 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes
All alleles(9) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(2) Chemically induced(3)
Null mutants grow slowly and die by 7 days of age with ketoacidosis, high serum insulin and triglycerides, low glycogen stores and fatty livers. Tissue specific knockouts show milder lipid metabolism anomalies. Point mutation heterozygotes exhibit hyperglycemia, hyperinsulinemia and glucosuria.
Polymorphisms RFLP(2) SNPs within 2kb(472 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(28)
Process exocrine pancreas development, insulin receptor signaling pathway...
Component caveola, integral to membrane...
Function ATP binding, kinase activity...
External Resources: MouseFunc
Expression Literature Summary: (12 records)
Data Summary: Assays (3)    Results (13)    Tissues (10)    Images (2)
Theiler Stages: 2,3,5,11,13,15,28
  Assay Type Assays   Results
      RT-PCR 3   13
cDNA source data(73)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(83) Genomic(5) cDNA(74) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
EC 2.7.10.1
Ensembl Gene Model ENSMUSG00000005534, ENSMUSG00000074498
DoTS DT.101254833, DT.40156503
UniGene 268003
PDB 1LK2
DFCI TC1598723, TC1618223, TC1731374
NIA Mouse Gene Index U029533
Entrez Gene 16337
VEGA Gene Model OTTMUSG00000031438
International Mouse Knockout Project Status Insr
Protein
domains
InterPro ID Description
IPR000494 EGF receptor, L domain
IPR000719 Protein kinase, catalytic domain
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
IPR003961 Fibronectin, type III
IPR006211 Furin-like cysteine-rich domain
IPR006212 Furin-like repeat
IPR008266 Tyrosine-protein kinase, active site
IPR008957 Fibronectin, type III-like fold
IPR009030 Growth factor, receptor
IPR011009 Protein kinase-like domain
IPR016246 Tyrosine-protein kinase, insulin-like receptor
IPR017441 Protein kinase, ATP binding site
IPR020710 Tyrosine-protein kinase, insulin receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:9626 Wang LM et al., "Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors." Genomics 1988 Aug;3(2):172-6
(Latest) J:152239 Rajala RV et al., "Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors." J Neurochem 2009 Sep;110(5):1648-60
All references(146)
Other
accession IDs
MGD-MRK-11417, MGI:2442502, MGI:2443766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory