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Ins2 Gene Detail
 Symbol
Name
ID
Ins2
insulin II
MGI:96573

Nomenclature History
Synonyms Ins-2, InsII, Mody, Mody4
Genetic Map
Chromosome 7
69.1 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 36)

Sequence Map
Chr7:149864561-149885415 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ins2 ± 2 cM)
Protein SuperFamily: insulin
TreeFam: TF332820
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000018794 VEGA Gene Model | MGI Sequence Detail 20855 C57BL/6J ± Kb
transcript NM_008387 RefSeq | MGI Sequence Detail 458 C57BL/6
polypeptide P01326 UniProt | EBI | MGI Sequence Detail 110 Not Applicable
For the selected sequences
All sequences(29)
Alleles
and
phenotypes 		All alleles(118) : Targeted, knock-out(2) Targeted, other(7) Gene trapped(107) Spontaneous(1) Chemically induced(1)
Mice homozygous for spontaneous or knock-out alleles exhibit increased mortality, abnormal growth, abnormal glucose homeostasis, impaired pancreatic function, and phenotypes associated with type 2 diabetes.
Associated Human Diseases (4)   Alleles Annotated to Human Diseases (2)   Phenotype Images (3)  
Polymorphisms All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(31 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of MAPK activity, carbohydrate metabolic process...
Component cytoplasm, extracellular region...
Function hormone activity
External Resources: FuncBase
Expression Literature Summary: (203 records)
Data Summary: Assays (47)    Results (243)    Tissues (107)    Images (83)
Theiler Stages: 2,3,5,11,13,14,15,16,17,18,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 24   166
      RNA in situ 3   8
      Immunohistochemistry 20   69
cDNA source data(141)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(190) Genomic(30) cDNA(141) Primer pair(16) Other(3) Antibodies(11)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000000215
DoTS DT.101400113, DT.101400114, DT.103585207, DT.103585231, DT.94397640
Consensus CDS Project CCDS22034.1
UniGene 4946
DFCI TC1573941, TC1594024, TC1652536
NIA Mouse Gene Index U029487
Entrez Gene 16334
VEGA Gene Model OTTMUSG00000018794
International Mouse Knockout Project Status Ins2
Protein
domains
InterPro ID Description
IPR004825 Insulin/IGF/relaxin
IPR016179 Insulin-like
Graphical View of Protein Domain Structure
References
(Earliest) J:6658 Goldfeld AE et al., "Genetic control of insulin receptors." Proc Natl Acad Sci U S A 1981 Oct;78(10):6359-61
(Latest) J:155929 Soyer J et al., "Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development." Development 2010 Jan;137(2):203-12
All references(330)
Other
accession IDs 		MGD-MRK-11411, MGD-MRK-11414, MGD-MRK-39550, MGI:109551, MGI:2141856
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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