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Idh1 Gene Detail
 Symbol
Name
ID
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
MGI:96413


Nomenclature History
Synonyms E030024J03Rik, Id-1, Idh-1, IDPc
Genetic Map
Chromosome 1
29.8 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 95)

Sequence Map
Chr1:65205190-65225755 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; gorilla; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Idh1 ± 2 cM)
Protein SuperFamily: isocitrate dehydrogenase (NADP)
TreeFam: TF300428
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021898 VEGA Gene Model | MGI Sequence Detail 20566 C57BL/6J ± Kb
transcript NM_001111320 RefSeq | MGI Sequence Detail 2292 C57BL/6
polypeptide O88844 UniProt | EBI | MGI Sequence Detail 414 Not Applicable
For the selected sequences
All sequences(41)
Alleles
and
phenotypes
All alleles(11) : Gene trapped(11)
Electrophoretic variation has been shown in tissues of liver, kidney, spleen and muscle. Strains C57BL/6, C3H/He carry the a allele; DBA/2 carries the b allele; M.m. castaneus and M.m. molossinus carry the c allele; the d allele is found at low frequency in M. m. molossinus in Japan.
Polymorphisms SNPs within 2kb(150 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(18)
Process glutathione metabolic process, glyoxylate cycle...
Component cytoplasm, cytosol...
Function isocitrate dehydrogenase (NADP+) activity, magnesium ion binding...
External Resources: MouseFunc
Expression Literature Summary: (3 records)
Data Summary: Assays (3)    Results (109)    Tissues (99)    Images (17)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 3   109
cDNA source data(16)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Pathways
TCA cycle variation II
TCA cycle
Other database
links
EC 1.1.1.42
Ensembl Gene Model ENSMUSG00000025950
DoTS DT.102557514, DT.536647, DT.91293161, DT.97355719, DT.99860968
PDB 2CMJ, 2CMV
DFCI TC1573539, TC1683672, TC1691717, TC1738050
NIA Mouse Gene Index U021417
Entrez Gene 15926
VEGA Gene Model OTTMUSG00000021898
International Mouse Knockout Project Status Idh1
Protein
domains
InterPro ID Description
IPR001804 Isocitrate/isopropylmalate dehydrogenase
IPR004790 Isocitrate dehydrogenase NADP-dependent, eukaryotic
IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:13010 HENDERSON NS, "ISOZYMES OF ISOCITRATE DEHYDROGENASE: SUBUNIT STRUCTURE AND INTRACELLULAR LOCATION." J Exp Zool 1965 Apr;158():263-73
(Latest) J:149737 Sansom SN et al., "The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis." PLoS Genet 2009 Jun;5(6):e1000511
All references(99)
Other
accession IDs
MGD-MRK-11152, MGD-MRK-11180, MGD-MRK-11183, MGI:2138196, MGI:2138322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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