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Hras1 Gene Detail
 Symbol
Name
ID
Hras1
Harvey rat sarcoma virus oncogene 1
MGI:96224


Nomenclature History
Synonyms c-H-ras, c-rasHa, H-ras, Ha-ras, Harvey-ras, Hras-1, ras
Genetic Map
Chromosome 7
72.2 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 31)

Sequence Map
Chr7:148375004-148379904 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; dog, domestic; hamster, Chinese; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Hras1 ± 2 cM)
Protein SuperFamily: ras protein
TreeFam: TF312796
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016471 VEGA Gene Model | MGI Sequence Detail 4901 C57BL/6J ± Kb
transcript NM_001130444 RefSeq | MGI Sequence Detail 2272 -
polypeptide Q61411 UniProt | EBI | MGI Sequence Detail 189 Not Applicable
For the selected sequences
All sequences(39)
Alleles
and
phenotypes
All alleles(8) : Targeted, knock-out(3) Targeted, other(3) Gene trapped(2)
Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (3)  
Polymorphisms RFLP(12) SNPs within 2kb(1 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell aging, cell proliferation...
Component Golgi apparatus, intracellular...
Function GTP binding, GTPase activity...
External Resources: FuncBase
Expression Literature Summary: (16 records)
Data Summary: Assays (10)    Results (46)    Tissues (28)    Images (5)
Theiler Stages: 5,20,21,22,23,25,28
  Assay Type Assays   Results
      Western blot 6   21
      RT-PCR 1   13
      RNA in situ 1   3
      Immunohistochemistry 2   9
cDNA source data(65)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(80) Genomic(9) cDNA(65) Primer pair(1) Other(5) Antibodies(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025499
DoTS DT.101380088, DT.101380090, DT.534773, DT.55194301
Consensus CDS Project CCDS22003.1
UniGene 334313
DFCI TC1580214, TC1599731, TC1613453, TC1619526, TC1685708
NIA Mouse Gene Index U029447
Entrez Gene 15461
VEGA Gene Model OTTMUSG00000016471
International Mouse Knockout Project Status Hras1
Protein
domains
InterPro ID Description
IPR001806 Ras GTPase
IPR003577 Ras small GTPase, Ras type
IPR005225 Small GTP-binding protein
IPR013753 Ras
IPR015592 Ras small GTPase, Ras-related
IPR020849 Ras small GTPase
Graphical View of Protein Domain Structure
References
(Earliest) J:6408 Shih TY et al., "Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus." Nature 1980 Oct 23;287(5784):686-91
(Latest) J:151146 Viosca J et al., "Germline expression of H-Ras(G12V) causes neurological deficits associated to Costello syndrome." Genes Brain Behav 2009 Feb;8(1):60-71
All references(129)
Other
accession IDs
MGD-MRK-10930, MGD-MRK-10931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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