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Hr Gene Detail
 Symbol
Name
ID
Hr
hairless
MGI:96223


Nomenclature History
Synonyms ba, bldy, N, rh, rh-bmh
Genetic Map
Chromosome 14
40.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 28)

Sequence Map
Chr14:70953863-70973345 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Hr ± 2 cM)
TreeFam: TF324723
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000022096 Ensembl Gene Model | MGI Sequence Detail 19483 C57BL/6J ± Kb
transcript NM_021877 RefSeq | MGI Sequence Detail 5599 -
polypeptide Q61645 UniProt | EBI | MGI Sequence Detail 1182 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes
All alleles(22) : Targeted, knock-out(1) Transgenic(1) Spontaneous(14) Chemically induced(6)
Mutant homozygotes exhibit hairloss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
Associated Human Diseases (3)   Alleles Annotated to Human Diseases (5)   Phenotype Images (9)  
Polymorphisms All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(103 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(10)
Process negative regulation of transcription, regulation of transcription...
Component nuclear body, nucleus...
Function DNA binding, metal ion binding...
External Resources: MouseFunc
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (9)    Tissues (3)    Images (2)
Theiler Stages: 28
  Assay Type Assays   Results
      RNA in situ 1   1
      Northern blot 2   8
cDNA source data(37)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(49) Genomic(10) cDNA(37) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022096
DoTS DT.40152518
UniGene 7598
DFCI TC1581479
NIA Mouse Gene Index U015825
Entrez Gene 15460
International Mouse Knockout Project Status Hr
Protein
domains
InterPro ID Description
IPR003347 Transcription factor jumonji/aspartyl beta-hydroxylase
IPR013129 Transcription factor jumonji
Graphical View of Protein Domain Structure
References
(Earliest) J:2405 Brooke HC, "Hairless mice" J Hered 1926;17():173-74
(Latest) J:153732 Kimura Y et al., "Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice." J Nutr 2009 Nov;139(11):2079-86
All references(168)
Other
accession IDs
MGD-MRK-10929, MGI:1890458, MGI:2661845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory