Symbol
Name
ID
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Synonyms
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hcp, Hcph, Ptp1C, SHP-1, Spin
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(40)
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Alleles
and
phenotypes
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All alleles(6) :
Targeted, other(1)
Gene trapped(1)
Spontaneous(3)
Chemically induced(1)
| Homozygous mutants are immunodeficient and autoimmune and exhibit neutrophilic skin lesions that disrupt hair follicles and give the motheaten appearance. Alleles vary in severity, with death occurring at 6-9 weeks postnatally due to severe pneumonitis. |
Phenotype Images (3)
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Polymorphisms
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All PCR and RFLP(2) :
PCR(1)
RFLP(1)
SNPs within 2kb(46 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (4 records)
Data Summary:
Assays (2)
Results (5)
Tissues (5)
Theiler Stages: 10,18,21,23,25
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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1 |
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Northern blot |
1 |
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4 |
cDNA source data(63)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
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All nucleic(70)
Genomic(3)
cDNA(65)
Primer pair(2)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000242 |
Protein-tyrosine phosphatase, receptor/non-receptor type |
| IPR000387 |
Dual-specific/protein-tyrosine phosphatase, conserved region |
| IPR000980 |
SH2 motif |
| IPR012152 |
Protein-tyrosine phosphatase, non-receptor type-6, -11 |
| IPR016130 |
Protein-tyrosine phosphatase, active site |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:13520
Green MC,
"Cribriform degeneration, cri"
Mouse News Lett 1971;45():29
(Latest)
J:155341
Inoue T et al.,
"SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways."
Mol Immunol 2009 Dec;47(2-3):222-32
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All references(151)
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Other
accession IDs
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MGD-MRK-10672, MGD-MRK-12181
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Analysis Tools
MGI BioMart
