Symbol
Name
ID
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(38)
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Alleles
and
phenotypes
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All alleles(43) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(41)
| Embryos homozygous for a targeted null mutation lack expanded inner cell masses, show only a few endodermal cells, and die by embryonic day 7.5. Heterozygotes have defective T cell signaling and lack the cardiac hypertrophy response to pressure overload. |
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Polymorphisms
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RFLP(1)
SNPs within 2kb(169 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (9 records)
Data Summary:
Assays (5)
Results (152)
Tissues (84)
Images (2)
Theiler Stages: 13,15,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
2 |
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92 |
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RNA in situ |
1 |
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47 |
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Northern blot |
2 |
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13 |
cDNA source data(151)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(155)
Genomic(2)
cDNA(152)
Primer pair(1)
Microarray probesets(3)
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Other database
links
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Protein
domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:23345
Lowenstein EJ et al.,
"The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling."
Cell 1992 Aug 7;70(3):431-42
(Latest)
J:148990
Haines E et al.,
"Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation."
Mol Cell Biol 2009 May;29(10):2505-20
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All references(54)
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Other
accession IDs
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MGD-MRK-10242, MGI:2143976
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Analysis Tools
MGI BioMart
